Results 41 to 50 of about 2,594,639 (259)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Marginal grafts increase early mortality in liver transplantation

open access: yesSão Paulo Medical Journal
CONTEXT AND OBJECTIVE: Expanded donor criteria (marginal) grafts are an important solution for organ shortage. Nevertheless, they raise an ethical dilemma because they may increase the risk of transplant failure.
Telesforo Bacchella   +5 more
doaj   +1 more source

Factors associated with implant marginal bone resorption after implant restoration in elderly patients with severe periodontitis [PDF]

open access: yesXin yixue
Objective To analyze the factors related to implant marginal bone resorption after implant restoration in elderly patients with severe periodontitis. Methods One hundred and ninety-five elderly patients with severe periodontitis who underwent implant ...
LI Yue, MA Yanru
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Marginal Benefit of Industrial Water Use in Northern China and Its Influencing Factors

open access: yesRenmin Zhujiang, 2022
With the data on the economic indicators,such as industrial water use,industrial added value,fixed-asset investment,and the number of employees,of the northern region for 2011—2020,this study employed an improved Cobb-Douglas production function to ...
DIAO Zicheng, ZHAO Jing, HAN Yuping
doaj  

Image Enhancement via Special Functions and Its Application for Near Infrared Imaging

open access: yesGlobal Challenges, 2023
Image enhancement is important given that it can be used to highlight the area of interest in the images. This article designs four filters via special function for realizing image enhancement.
Ruoxi Yang   +5 more
doaj   +1 more source

Contextual and variational contrast enhancement [PDF]

open access: yes, 2011
This paper proposes an algorithm which enhances the contrast of an input image using inter-pixel contextual information. The algorithm uses a two-dimensional (2D) histogram of the input image constructed using mutual relationship between each pixel and ...
Tjahjadi, Tardi   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Marginal deformations of SU(2) k WZW model boundary states in open string field theory

open access: yesJournal of High Energy Physics
We attempt to describe the moduli space of boundary states in the SU(2) k WZW model by constructing marginally deformed solutions in open string field theory in the level truncation approximation.
Matěj Kudrna
doaj   +1 more source

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