Results 61 to 70 of about 262,287 (308)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Journal of Marine Science and EngineeringA joint distribution of significant wave heights (Hs) and peak wave periods (Tp) in the northwestern South China Sea is created using a conditional distribution model in this work.
Gongpeng Liu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Bivariate Distributions with Given Marginals
The Annals of Statistics, 1976 Bivariate distributions with minimum and maximum correlations for given marginal distributions are characterized. Such extremal distributions were first introduced by Hoeffding (1940) and Frechet (1951). Several proofs are outlined including ones based on rearrangement theorems. The effect of convolution on correlation is also studied.
openaire +3 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Analysis of Ferquency Maximum Flood in Mountain basin (Case study : Armand station) [PDF]
علوم و مهندسی آبیاری, 2012 A bivariate extreme value distribution, namely the Gumbel mixed model constructed from Gumbel marginal distributions is employed to analyze the joint distribution of correlated flood peak (probable maximum flood) and amount.
D. Rahimi, A. Baratian
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Marginal Distribution Multi-Target Bayes Filter With Assignment of Measurements
IEEE Access, 2020 This work proposes a marginal distribution multi-target Bayes filter with assignment of measurements to track multiple targets in the presence of an unknown and variable number of targets, clutter, and missed detections.
Zong-Xiang Liu, Mian Wu, Jie Gan
doaj +1 more source
Inequalities for Distributions with Given Marginals
The Annals of Probability, 1980 An ordering on discrete bivariate distributions formalizing the notion of concordance is defined and shown to be equivalent to stochastic ordering of distribution functions with identical marginals. Furthermore, for this ordering, $\int\varphi dH$ is shown to be $H$-monotone for all superadditive functions $\varphi$, generalizing earlier results of ...
openaire +3 more sources
Change-point detection in the marginal distribution of a linear process
, 2016 © 2016, Institute of Mathematical Statistics. All rights reserved. The subject of this paper is the detection of a change in the marginal distribution of a stationary linear process.
El Ktaibi, Farid, Ivanoff, B. Gail
core +2 more sources