Results 61 to 70 of about 5,052,793 (311)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Generalized Bivariate Kummer-Beta Distribution
Ingeniería y Ciencia, 2020 A new bivariate beta distribution based on the Humbert’s confluent hypergeometric function of the second kind is introduced. Various representations are derived for its product moments, marginal densities, marginal moments, conditional densities and ...
Daya K. Nagar +2 more
doaj +1 more source
Bayesian Inference for Seasonal ARMA Models [PDF]
The Egyptian Statistical Journal, 1987 An essential ingredient of any time series anatysis is the estimation of the modcl parameters. The main objective of this paper is to develop a convenient Rayesian technique for estimation which can be used to analyze ‘seasonal autoregressive moving ...
Samir Shaarawy, Mohamed Ismail
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Marginal and conditional distributions of singular distributions
Publications of the Research Institute for Mathematical Sciences, 1965 This note derives marginal and conditional means and covariances when the joint distribution may be singular and discusses the resulting invariants.
Harris, W. A. jun., Helvig, T. N.
openaire +2 more sources
Comrade Black Distribution [February 1998 catalogue]
, 1998 The catalog of a D.I.Y. retail distributor of political and small press books and pamphlets. Started in 1996, CB Distribution is an effort to counter the homogeneity of political and artistic thought that dominates the mainstream media.
Comrade Black Distribution
core +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
International Journal of Electrical Power & Energy SystemsTraditional prices at the distribution level cannot efficiently guide the comprehensive cost recovery. To this end, this paper proposes a novel integrated nodal price by solving a comprehensive investment problem.
Zhaobin Wei +7 more
doaj +1 more source
A Kernel Method for the Optimization of the Margin Distribution [PDF]
, 2008 Recent results in theoretical machine learning seem to suggest that nice properties of the margin distribution over a training set turns out in a good performance of a classifier. The same principle has been already used in SVM and other kernel based methods as the associated optimization problems try to maximize the minimum of these margins.
AIOLLI, FABIO +2 more
openaire +1 more source
Improving Upon the Marginal Empirical Distribution Functions when the Copula is Known [PDF]
At the heart of the copula methodology in statistics is the idea of separating marginal distributions from the dependence structure. However, as shown in this paper, this separation is not to be taken for granted: in the model where the copula is known ...
Werker, B.J.M. +2 more
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