Results 41 to 50 of about 309,960 (266)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Exploring cycling flow dynamics and their interaction with built environment features: evidence from bike-sharing data

Geo-spatial Information Science
Understanding urban travel patterns through the lens of flow space is essential for analyzing urban structures and their dynamics. Cycling flows, in particular, offer valuable insights into these patterns.
Xiaoming Li, Shanlai Zou, Weixi Wang, Ding Ma, Renzhong Guo, Yixin Liu, Ye Zheng   +6 more
doaj   +1 more source

A robust model-free approach for rare variants association studies incorporating gene-gene and gene-environmental interactions. [PDF]

PLoS ONE, 2013
Recently more and more evidence suggest that rare variants with much lower minor allele frequencies play significant roles in disease etiology. Advances in next-generation sequencing technologies will lead to many more rare variants association studies ...
Ruixue Fan, Shaw-Hwa Lo
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Proceso de reestructuración bancaria: análisis de las entidades participantes, fusionadas y nacionalizadas || Bank Restructuring: Analysis of Participating, Merged and Nationalized Entities

Revista de Métodos Cuantitativos para la Economía y la Empresa, 2017
En la década de los noventa en el sector financiero se produjo un proceso sin precedentes de fusiones y adquisiciones en toda Europa. Esta tendencia se inició en Estados Unidos en los ochenta, extendiéndose rápidamente al continente europeo.
Jimber del Río, Juan Antonio, Caridad y Ocerin, José María, Ceular Villamandos, Nuria   +2 more
doaj  

Effects of 2D/3D Urban Morphology on Cooling Effect Diffusion of Urban Rivers in Summer: A Case Study of Huangpu River in Shanghai

Land
The diffusion effect of river cooling is critical for mitigating the urban heat island effect in riverside areas and for establishing an urban cooling network. River cooling effect diffusion is influenced by the two-dimensional (2D) and three-dimensional
Yuhui Wang, Shuo Sheng, Junda Huang, Yuncai Wang   +3 more
doaj   +1 more source

Simplified marginal effects in discrete choice models [PDF]

Economics Letters, 2003
Abstract We show that with a simple normalization of explanatory variables, marginal effects in probit and logit models simplify dramatically, becoming a function of only the estimated constant term. Related simplifications hold for computation of asymptotic variances of these effects.
Newell, Richard, Anderson, Soren
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Understanding Marginal Structural Models for Time-Varying Exposures: Pitfalls and Tips

Journal of Epidemiology, 2020
Epidemiologists are increasingly encountering complex longitudinal data, in which exposures and their confounders vary during follow-up. When a prior exposure affects the confounders of the subsequent exposures, estimating the effects of the time-varying
Tomohiro Shinozaki, Etsuji Suzuki
doaj   +1 more source

Identifying Gene–Environment Interactions With Robust Marginal Bayesian Variable Selection

Frontiers in Genetics, 2021
In high-throughput genetics studies, an important aim is to identify gene–environment interactions associated with the clinical outcomes. Recently, multiple marginal penalization methods have been developed and shown to be effective in G×E studies ...
Xi Lu, Kun Fan, Jie Ren, Cen Wu
doaj   +1 more source