Results 61 to 70 of about 9,847,554 (308)

Identifying Meteorological Determinants Associated with Roadway Crash Severity in Dhaka Metropolitan Area of Bangladesh: An Econometric Analysis over a Decade

Urban Science
This study investigates the impact of urban meteorological factors on road crash severity in Dhaka, Bangladesh. Using police crash data, and meteorological data from NASA POWER database for years 2011–2022, a generalized ordered logit model was used to ...
Nazmul Islam, Md. Ahnaf Zaman, Maheen Zaman, Nasif Ahmed Chowdhury, Armana Sabiha Huq, Sk Fateh Md Rasel   +5 more
doaj   +1 more source

Understanding Marginal Structural Models for Time-Varying Exposures: Pitfalls and Tips

Journal of Epidemiology, 2020
Epidemiologists are increasingly encountering complex longitudinal data, in which exposures and their confounders vary during follow-up. When a prior exposure affects the confounders of the subsequent exposures, estimating the effects of the time-varying
Tomohiro Shinozaki, Etsuji Suzuki
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Exploring cycling flow dynamics and their interaction with built environment features: evidence from bike-sharing data

Geo-spatial Information Science
Understanding urban travel patterns through the lens of flow space is essential for analyzing urban structures and their dynamics. Cycling flows, in particular, offer valuable insights into these patterns.
Xiaoming Li, Shanlai Zou, Weixi Wang, Ding Ma, Renzhong Guo, Yixin Liu, Ye Zheng   +6 more
doaj   +1 more source

Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies

BMC Genetics, 2017
Background Weighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions.
Anke Hüls, Ursula Krämer, Christopher Carlsten, Tamara Schikowski, Katja Ickstadt, Holger Schwender   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Rhizobial Inoculation Improves Soil Properties and Microbial Network Stability to Support Medicago sativa L. Production in Cold Arid Regions

Microorganisms
The Qinghai–Tibet Plateau, a globally significant ecological barrier and a core pastoral region, is persistently constrained by cold and arid climatic conditions, nutrient poor soils, and progressive grassland degradation.
Qianqian Zhao, Xin Jin, Chengti Xu, Guangxin Lu, Haijuan Zhang   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Potassium Fulvate Alleviates Salinity and Boosts Oat Productivity by Modifying Soil Properties and Rhizosphere Microbial Communities in the Saline–Alkali Soils of the Qaidam Basin

Agronomy
Soil salinization severely limits global agricultural sustainability, particularly across the saline–alkaline landscapes of the Qinghai–Tibet Plateau. We examined how potassium fulvate (PF) modulates oat (Avena sativa L.) performance, soil chemistry, and
Jie Wang, Xin Jin, Xinyue Liu, Yunjie Fu, Kui Bao, Zhixiu Quan, Chengti Xu, Wei Wang, Guangxin Lu, Haijuan Zhang   +9 more
doaj   +1 more source