Results 51 to 60 of about 1,474,254 (309)

A robust model-free approach for rare variants association studies incorporating gene-gene and gene-environmental interactions. [PDF]

PLoS ONE, 2013
Recently more and more evidence suggest that rare variants with much lower minor allele frequencies play significant roles in disease etiology. Advances in next-generation sequencing technologies will lead to many more rare variants association studies ...
Ruixue Fan, Shaw-Hwa Lo
doaj   +1 more source

Simplified marginal effects in discrete choice models [PDF]

Economics Letters, 2003
Abstract We show that with a simple normalization of explanatory variables, marginal effects in probit and logit models simplify dramatically, becoming a function of only the estimated constant term. Related simplifications hold for computation of asymptotic variances of these effects.
Newell, Richard, Anderson, Soren
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Inequality and Total Effect Summary Measures for Nominal and Ordinal Variables

Sociological Science
Many of the topics most central to the social sciences involve nominal groupings or ordinal rankings. There are many cases in which a summary of a nominal or ordinal independent variable's effect, or the effect on a nominal or ordinal outcome, is needed ...
Trenton D. Mize, Bing Han
doaj   +1 more source

Understanding Marginal Structural Models for Time-Varying Exposures: Pitfalls and Tips

Journal of Epidemiology, 2020
Epidemiologists are increasingly encountering complex longitudinal data, in which exposures and their confounders vary during follow-up. When a prior exposure affects the confounders of the subsequent exposures, estimating the effects of the time-varying
Tomohiro Shinozaki, Etsuji Suzuki
doaj   +1 more source

The Effects of Marginal Deviations on Behavioral Development [PDF]

European Psychologist, 2006
This investigation was conceptually framed within the theory of marginal deviations ( Caprara & Zimbardo, 1996 ) and sought evidence for the general hypothesis that some children who initially show marginal behavioral problems may, over time, develop more serious problems depending partly on other personal and behavioral characteristics.
CAPRARA, Gian Vittorio, Kenneth A. Dodge, PASTORELLI, Concetta, Arnaldo Zelli   +3 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies

BMC Genetics, 2017
Background Weighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions.
Anke Hüls, Ursula Krämer, Christopher Carlsten, Tamara Schikowski, Katja Ickstadt, Holger Schwender   +5 more
doaj   +1 more source