Results 91 to 100 of about 17,919,150 (332)

Quantities of Interest for Interactions and the Pitfalls of Assuming Linear Treatment Effects

Sociological Science
Although quantitative social sciences often rely on estimating models in which treatment effects vary across groups, researchers rarely specify which causal quantity they aim to estimate or justify their empirical modeling choices. This article makes two
Josep Serrano-Serrat
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Infiltração marginal de cimentos de ionômero de vidro utilizados no art com diferentes técnicas de inserção - estudo in vitro [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em OdontologiaForam avaliados o grau de infiltração marginal de dois cimentos de ionômero de vidro utilizados no ART em restaurações ...
Nogueira, Danielle Aparecida
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The Fiscal Costs of Unemployment Insurance

Economía
This paper studies the fiscal costs of unemployment insurance (UI). It surveys alternative methods used in the literature to estimate the impact of UI on government budgets and compares them within a unified framework that incorporates behavioral ...
Joaquín Herrera, Martin Gonzalez-Rozada, Hernán Ruffo   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Effects of zinc deficiency and arsenic exposure on bone in growing female mice

Scientific Reports
Arsenic contamination in groundwater often co-exists in regions prone to zinc deficiency. The goal of this research was to evaluate the independent and combined effects of zinc status [adequate, marginally-deficient, severely-deficient (30, 6, and 
Laura M. Beaver, Carmen P. Wong, Sarah Hasler, Maud Prati, Erica J. Dashner-Titus, Emily Ho, Adam J. Branscum, Russell T. Turner, Urszula T. Iwaniec   +8 more
doaj   +1 more source

Estimating treatment effects on the marginal recurrent event mean in the presence of a terminating event

Lifetime Data Analysis, 2010
In biomedical studies where the event of interest is recurrent (e.g., hospitalization), it is often the case that the recurrent event sequence is subject to being stopped by a terminating event (e.g., death).
D. Schaubel, Min Zhang
semanticscholar   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Marginal employment: Stepping stone or dead end? : evaluating the German experience [PDF]

"'Marginal employment', i. e. employment with low working hours and earnings not covered by social security, has been gaining importance in the German economy over the past decade.
Steiner, Viktor, Freier, Ronny
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