Results 71 to 80 of about 17,919,150 (332)

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Modeling Temporal Dependence of Average Surface Treating Pressure in the Williston Basin Using Dynamic Multivariate Regression

open access: yesEnergies, 2022
The oil and gas industry has shifted paradigms after seeing the drastic decrease in oil prices since 2015. Companies are now focused as much on cost reduction as much as production maximization to drive profitable operations.
Josh Kroschel   +2 more
doaj   +1 more source

Heterogeneous Treatment Effects in the Presence of Self-Selection: A Propensity Score Perspective

open access: yesSociological methodology, 2019
An essential feature common to all empirical social research is variability across units of analysis. Individuals differ not only in background characteristics but also in how they respond to a particular treatment, intervention, or stimulation. Moreover,
Xiaoping Zhou, Yu Xie
semanticscholar   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Very simple marginal effects in some discrete choice models [PDF]

open access: yes
I show a simple back-of-the-envelope method for calculating marginal effects in binary choice and count data models. The approach suggested here focuses attention on marginal effects at different points in the distribution of the dependent variable ...
Kevin J. Denny
core   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Unpacking the treatment effects on the decision to steal: Marginal effects probit estimator.

open access: yes, 2023
Unpacking the treatment effects on the decision to steal: Marginal effects probit estimator.
Nattavudh Powdthavee (7455494)   +3 more
core   +1 more source

Partial Identification of Marginal Treatment Effects with discrete instruments and misreported treatment [PDF]

open access: yes, 2023
This paper provides partial identification results for the marginal treatment effect ($MTE$) when the binary treatment variable is potentially misreported and the instrumental variable is discrete.
Acerenza, Santiago
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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