Results 41 to 50 of about 258,757 (279)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Marginalisation and stereotypes relating to the elderly in the context of social changes and family problems. Generation gap and methods of prevention in Poland

Journal of Modern Science
Objectives The general aim of the present study is the sociological conceptualization of the problem of social marginalization and stereotypes relating to old people by the analysis of the “generation gap”, its factors and indicators as well as ...
Bartosz Łukaszewski, Leon Szot, Mirosław Kalinowski, Iwona Niewiadomska   +3 more
doaj   +1 more source

Regard sur la participation de populations marginalisées à la recherche-action. Le cas des squatteurs en Ile-de-France

Revue Interventions Économiques, 2011
Research-Action has two main objectives: to allow different players to cooperate, and to transform social reality. This methodology has both the strengths and the weaknesses of strictly cognitive research.
Anne Petiau, Lionel Pourtau
doaj   +1 more source

Margins! Margins. Margins? How Important Is Margin Status in Breast-Preserving Therapy? [PDF]

Breast Care, 2011
Margin status is surely a prognostic factor in patients undergoing breast-conserving therapy, but its impact is probably overestimated in case of adequate adjuvant radiotherapy. Radiotherapy improves local control after excision of the primary tumor in all subgroups of patients.
Jürgen, Dunst, Kathrin, Dellas
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Care, co-survival, and decency: expanding the understanding of outdoor life and smaller alcohol and drug scenes in Denmark and Norway

Frontiers in Psychiatry
IntroductionPublic spaces where alcohol and other drugs are openly used and marginal citizens gather, exist in many Nordic cities. The biggest open drug scenes in the Nordic countries are in cities like Oslo and Copenhagen; however, there are smaller ...
Jonas Strandholdt Bach, Trond Erik Grønnestad, Anne Schanche Selbekk, Anne Schanche Selbekk, Vilde Holan Bye, Amanda Skjong   +5 more
doaj   +1 more source

Disability, Religion, and Gender: Exploring Experiences of Exclusion in India Through an Intersectional Lens

Social Inclusion, 2023
Despite the existence of national and international laws and conventions to avoid discrimination in India, exclusion due to an intersection of disability, gender, and religious identity continues, resulting in marginalisation from society.
Stephen Thompson, Brigitte Rohwerder, Dolon Mukherjee   +2 more
doaj   +1 more source

Cosmic Acceleration Data and Bulk-Brane Energy Exchange [PDF]

, 2007
We consider a braneworld model with bulk-brane energy exchange. This allows for crossing of the w=-1 phantom divide line without introducing phantom energy with quantum instabilities.
C. Bogdanos, K. Tamvakis, L. Perivolaropoulos, S. Nesseris, S. M. Carroll, V. Sahni   +5 more
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Religious Indoctrination or Marginalization Theory? Muslim-Christian Public Discourses and Perceptions on Religious Violence in Kenya [PDF]

Journal for the Study of Religion, 2017
The numerous killings of non-Muslims by Muslim jihadi groups in Kenya, have fuelled ethno-religious tensions manifested in hatred and anger against the entire Muslim community.
Hassan J. Ndzovu
doaj   +1 more source