Results 111 to 120 of about 7,749,636 (269)

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu   +15 more
wiley   +1 more source

Uncommon Association of Two Anatomical Variants of Cerebral Circulation: A Fetal-Type Posterior Cerebral Artery and Inferred Artery of Percheron, Complicated with Paramedian Thalamomesencephalic Stroke—Case Presentation and Literature Review

open access: yesCase Reports in Neurological Medicine, 2018
Background. The unilateral fetal variant of the posterior cerebral artery (FPCA) is characterized by the congenital absence of the P1 arterial segment.
Aurelian Anghelescu
doaj   +1 more source

Illicit Drug Use and Educational Attainment [PDF]

open access: yes
This paper uses data from the National Education Longitudinal Study to estimate the association between illicit drug use during high school and the number of years of schooling completed.
Pinka Chatterji
core  

Efficacy and Safety of Cannabis Derivates and Their Synthetic Analogs. Overview of Systematic Reviews

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT The use of medicinal products derived from cannabis and its synthetic analogues has grown in recent years for various health conditions, which led to an increase in systematic reviews (SR) on the topic. The objective of this overview was to identify, synthesize, and critically appraise the evidence from SR on the benefits and harms of cannabis
Rafael Leite Pacheco   +5 more
wiley   +1 more source

The indirect effects of discrimination on substance use in bisexual adults through internalized binegativity, concealment, and distress tolerance

open access: yesAddictive Behaviors Reports
Purpose: Bisexual people experience bisexual-specific stressors (e.g., anti-bisexual discrimination, internalized binegativity) that impact health outcomes.
Tarik D. Goulbourne   +3 more
doaj   +1 more source

Plant‐Derived Extracellular Vesicles: Biogenesis, Function, and Application in Cancer Immunotherapy

open access: yesPhytotherapy Research, EarlyView.
This illustration shows the biogenesis pathways of edible and medicinal plant‐derived extracellular vesicles (PDEVs) and their therapeutic effects following uptake in the human body, highlighting their potential for application in cancer immunotherapy. ABSTRACT Plant‐derived extracellular vesicles (PDEVs) are nanoscale, lipid bilayer‐enclosed vesicles ...
Guosheng Li   +4 more
wiley   +1 more source

Advances in Unconventional and Sustainable Synthetic Approaches to Benzopyran Scaffolds

open access: yesThe Chemical Record, EarlyView.
This review provides a comprehensive and critical analysis of low‐impact synthetic methodologies reported in the last 8 years (2018–2026) for the construction of benzopyran‐derived scaffolds, such as coumarins, flavones, chromones, chromenes, and chromanes. The benzopyran scaffold is a versatile family of heterocycles found in a wide range of bioactive
Nathalia B. Sá   +4 more
wiley   +1 more source

Of Green Institutions and Incremental Policies: Marijuana Regulatory Reform

open access: yes, 2012
Lecture delivered on Tuesday, November 27th, 2012 by Dr. Jason Plume for the Humboldt Institute for Interdisciplinary Marijuana Research First Annual Speaker Series. Dr. Plume teaches in the Department of Politics at Humboldt State University.
Plume, Jason
core  

Crafting the Future: Developing Graduate Programs Aligned With Demographic Trends

open access: yesNew Directions for Teaching and Learning, EarlyView.
ABSTRACT In response to changing student demographics and increasing budget constraints, many colleges and universities are reevaluating their graduate education strategies. While some institutions are striving to save costs via program cuts and layoffs, others are refocusing attention on student recruitment, specifically targeting working adults as a ...
Jennifer A. Owens   +2 more
wiley   +1 more source

Impacts of Global Cannabis Policy Changes on Substance Use: A Systematic Review of Quasi‐Experimental Studies

open access: yesThe Milbank Quarterly, EarlyView.
Policy Points The liberalization of medical and recreational cannabis policies may increase cannabis initiation across age groups, with increased prevalence of cannabis use among young adults and adults and weaker effects among youth. Evidence also suggests increases in cannabis‐related health care utilization among adults.
SARAH B. WINDLE   +8 more
wiley   +1 more source

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