Results 221 to 230 of about 7,749,636 (269)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Impact of problematic substance use and social anxiety on school functioning: Insights from the Texas Youth Depression and Suicide Research Network. [PDF]

PLOS Ment Health
Baronia R, Minshall BL, Minhajuddin A, Goodman LC, Marino EN, Egan D, Armstrong GM, Baughn D, Lokubandara AH, Martin SL, Soares JC, Wakefield SM, Trivedi MH.   +12 more
europepmc   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Recreational drug inhalation and socioenvironmental determinants of pulmonary infection in patients with HIV: a hospital-based case control study. [PDF]

BMC Public Health
Blount RJ, Fong S, Stone S, Falahati V, Auld E, Balmes J, Huang L.   +6 more
europepmc   +1 more source

Sex differences in stress responding in a randomized, placebo-controlled clinical trial of progesterone in cannabis use disorder. [PDF]

Psychopharmacology (Berl)
Martin EL, Baker NL, Neelon B, Saladin ME, Gray KM, Watson Z, McRae-Clark AL.   +6 more
europepmc   +1 more source

Exploring the acceptability and feasibility of a blended imagery‐based digital intervention for self‐harm in young people (Imaginator 2.0): a co‐produced qualitative study

Child and Adolescent Mental Health, EarlyView.
Background Around 20% of 12‐ to 25‐year‐olds experience self‐harm, but interventions deemed both acceptable and effective in reducing self‐harm behaviour are rare. Digital interventions can be effective; however, they often lack sustained engagement and co‐design.
Lindsay H. Dewa, Athina Servi, Emily Gardner‐Bougaard, Saida Jabril Mohamed, Aaron McDermott, Ben Aveyard, Rachel Rodrigues, Adam Hampshire, Nejra Van Zalk, Martina Di Simplicio   +9 more
wiley   +1 more source

Delayed Traumatic Subarachnoid Hemorrhage Following Initially Negative Computed Tomography (CT) Imaging in a Patient With a Mechanical Mitral Valve and Markedly Elevated International Normalized Ratio (INR). [PDF]

Cureus
Sauers KN, Tomlinson PL, Hall TE.
europepmc   +1 more source

Parents With Substance Use Disorder in the Holding Tight Treatment System: Intervention Effectiveness and Moderating Effects

Child &Family Social Work, EarlyView.
ABSTRACT Parents with substance use disorder have multiple risks affecting their parenting. Mental health problems and adverse childhood experiences (ACEs) with problems in emotion regulation and adult attachment insecurity may impair the early interaction with the infant.
Saara J. Salo, Marjo Flykt, Yan Li, Mirjam Kalland, Marjukka Pajulo   +4 more
wiley   +1 more source

Clinical and behavioral predictors of HIV-associated neurocognitive disorder among people with HIV who use substances: a secondary analysis of the HOPE trial. [PDF]

J Neurovirol
Wang G, Yang X, Wang K, Li X, Dai Z, Qiao S.   +5 more
europepmc   +1 more source