Results 41 to 50 of about 2,156 (171)

Extreme Procoagulant Potency in Human Plasma of Venoms from the African Viperid Genera Atheris, Cerastes, and Proatheris and the Relative Efficacy of Antivenoms and Synthetic Enzyme-Inhibitors

Toxins, 2022
The African viperid snake genera Atheris, Cerastes, and Proatheris are closely related, similar in size, but occupy extremely divergent ecological niches (arboreal in tropical rainforests, fossorial in deserts, and swamp-dwelling, respectively).
Abhinandan Chowdhury, Matthew R. Lewin, Rebecca Carter, Raul Soria, Matt Aldridge, Bryan G. Fry   +5 more
doaj   +1 more source

Tumor necrosis factor α-converting enzyme inhibition reverses hepatic steatosis and improves insulin sensitivity markers and surgical outcome in mice. [PDF]

PLoS ONE, 2011
Hepatic steatosis is an established risk factor for complications following major hepatic resection. Pharmacological options to reverse steatosis prior to surgery, however, are lacking. We hypothesized that treatment with the pharmacologic tumor necrosis
Vincent E de Meijer, Hau D Le, Jonathan A Meisel, Anisha K Sharma, Yury Popov, Mark Puder   +5 more
doaj   +1 more source

Stepwise candidate drug screening for myopia control by using zebrafish, mouse, and Golden Syrian Hamster myopia models

EBioMedicine, 2021
Background: We developed a preclinical protocol for the screening of candidate drugs able to control myopia and prevent its progression. The protocol uses zebrafish, C57BL/6 mice, and golden Syrian hamster models of myopia.
Meng-Yin Lin, I-Tsen Lin, Yu-Ching Wu, I-Jong Wang   +3 more
doaj   +1 more source

Investigating the role of MMP9 in anti‐Abeta immunotherapy‐associated ARIA [PDF]

Alzheimers Dement
Abstract Background Amyloid related imaging abnormalities (ARIA) remain a major obstacle to the widespread use of anti‐amyloid immunotherapy. Data has indicated an association of neuroinflammation and subsequent MMP activation as being associated with anti‐amyloid immunotherapy.
Foley K, Weekman E, Krick K, Chalk J, Wilcock D.   +4 more
europepmc   +2 more sources

Profiling the immune response to anti‐Aβ immunotherapy [PDF]

Alzheimers Dement
Abstract Background As patients receive approved anti‐Aβ immunotherapies the critical need to understand the effects of anti‐Aβ antibody exposure on the brain is of extreme priority. We sought to identify immune changes in response to acute and chronic anti‐Aβ antibody to determine potential causes of neuroinflammation that may lead to ARIA (amyloid ...
Foley K, Krick K, Weekman E, Wilcock D.
europepmc   +2 more sources

Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib

Toxins, 2021
Bites from elapid snakes typically result in neurotoxic symptoms in snakebite victims. Neurotoxins are, therefore, often the focus of research relating to understanding the pathogenesis of elapid bites.
Taline D. Kazandjian, Arif Arrahman, Kristina B. M. Still, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Mark C. Wilkinson, Jeroen Kool   +7 more
doaj   +1 more source

Inhibition of MMPs supports amoeboid angiogenesis hampering VEGF-targeted therapies via MLC and ERK 1/2 signaling

Journal of Translational Medicine, 2023
Background In the past decades studies on anti-tumoral drugs inhibiting matrix metalloproteinase (MMPs) were disappointing. Recently, we demonstrated that mature endothelial cells (ECs) and endothelial colony forming cells (ECFCs) can switch between ...
Anastasia Chillà, Cecilia Anceschi, Elena Frediani, Francesca Scavone, Tommaso Del Rosso, Giuseppe Pelagio, Antonio Tufaro, Giuseppe De Palma, Mario Del Rosso, Gabriella Fibbi, Paola Chiarugi, Anna Laurenzana, Francesca Margheri   +12 more
doaj   +1 more source

Inhibition of Pathological Increased Matrix Metalloproteinase (MMP) Activity for Improvement of Bone Regeneration in Diabetes

Life, 2022
Patients with diabetes suffer from poor fracture healing. Molecular reasons are not fully understood and our previous gene expression microarray analyses of regenerating bones from mice with type 2 diabetes (db−/db−) revealed accelerated activation of ...
Johannes Maximilian Wagner, Felix Reinkemeier, Christoph Wallner, Mehran Dadras, Stephanie Dittfeld, Marius Drysch, Alexander Sogorski, Maxi von Glinski, Marcus Lehnhardt, Björn Behr, Mustafa Becerikli   +10 more
doaj   +1 more source

Dual Targeting of Cancer Cells and MMPs with Self-Assembly Hybrid Nanoparticles for Combination Therapy in Combating Cancer

Pharmaceutics, 2021
The co-delivery of chemotherapeutic agents and immune modulators to their targets remains to be a great challenge for nanocarriers. Here, we developed a hybrid thermosensitive nanoparticle (TMNP) which could co-deliver paclitaxel-loaded transferrin (PTX ...
Kai Zhang, Jingjing Li, Xiaofei Xin, Xiaoqing Du, Di Zhao, Chao Qin, Xiaopeng Han, Meirong Huo, Lei Yang, Lifang Yin   +9 more
doaj   +1 more source

Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins

Biomedicines, 2020
Animal-derived antivenoms are the only specific therapies currently available for the treatment of snake envenoming, but these products have a number of limitations associated with their efficacy, safety and affordability for use in tropical snakebite ...
Chunfang Xie, Laura-Oana Albulescu, Mátyás A. Bittenbinder, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool   +6 more
doaj   +1 more source