Results 121 to 130 of about 1,396,037 (289)

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

The real map of Ireland, Ireland's marine territory: word association and pictures [PDF]

, 2013
Ireland has a marine territory of up to 220 million acres (880,000km²) which is ten times the size of Irelands land area. The aim is to develop student’s perception that the map of “Ireland” also includes Ireland’s marine territory, thus introducing “The
Marine Institute
core   +2 more sources

A simple, robust, and inexpensive design for creating thermal refugia to protect amphibians from Batrachochytrium dendrobatidis in the field

Conservation Science and Practice, EarlyView.
Abstract The emergence and spread of wildlife diseases requires innovative, practical solutions to help vulnerable species survive in the wild. One promising approach involves exploiting mismatches in environmental tolerances between pathogens and their hosts to reduce disease impacts.
Ewen K. Lawler, Richard P. Duncan, Jarrod Sopniewski, Ben C. Scheele, Simon Clulow   +4 more
wiley   +1 more source

Proceedings of the 2nd Annual Beaufort Marine Biodiscovery Research Workshop [PDF]

, 2010
This publication presents the background and aims of the 2nd Annual Marine Biodiscovery Workshop 2009. Presentations relating to progress achieved in the marine biodiscovery research area through the Irish Beaufort Marine Biodiscovery Research Awards ...
Nardello, I.
core   +2 more sources

Structural and mutational analysis of Methanosarcina mazei prenylated FMN synthase reveals the basis of its unique prenyl donor substrate specificity

The FEBS Journal, EarlyView.
Some prenylated flavin mononucleotide (prFMN) synthases exceptionally prefer dimethylallyl phosphate (DMAP) over dimethylallyl diphosphate (DMAPP), which is a common prenyl donor substrate for many prenyltransferases. Structural and mutagenic analyses of Methanosarcina mazei prFMN synthase, which prefers DMAP but can also accept DMAPP, elucidated its ...
Sou Fukuhara, Hideaki Unno, Soma Ishimine, Ryuhei Nagata, Tomokazu Ito, Hisashi Hemmi   +5 more
wiley   +1 more source

Lanspora dorisauae, a new marine fungus from rocky shores in Taiwan. [PDF]

PeerJ, 2023
Pang KL, Guo SY, Shaumi A, Suetrong S, Klaysuban A, Chiang MWL, Jones EBG.   +6 more
europepmc   +1 more source

A guide to host genetic determinants of female microbiome composition across distinct anatomical niches

The FEBS Journal, EarlyView.
Host genetic variation in immune regulation and cell signalling genes was associated with microbiome composition across vaginal, gut, oral and skin sites, while associations involving metabolic function, epithelial barrier integrity and hormonal processes were more site‐specific. Overall, our findings indicate that host genetic variation contributes to
Isabella Margaret Davidson, Elham Nikbakht, Hayley O'Neill, Larisa Margaret Haupt, Paul Joseph Dunn   +4 more
wiley   +1 more source

Breaking the ice: multiple origins of ice‐binding/antifreeze proteins

The FEBS Journal, EarlyView.
Ice‐binding proteins (IBPs) evolved independently in many organisms during Cenozoic cooling and glaciation. In flounders, α‐helical IBPs evolved from an antiviral protein, while similar IBPs arose independently from different progenitors in three other fish lineages.
Laurie A. Graham, Peter L. Davies
wiley   +1 more source

Acute freshwater CO2 exposure does not impair seawater transfer in three different sizes of Atlantic salmon (Salmo salar) subjected to different photoperiod manipulations

Journal of Fish Biology, EarlyView.
Abstract There is a growing interest in Atlantic salmon (Salmo salar) aquaculture to extend the time fish are reared in freshwater (FW) recirculating aquaculture systems (RAS), producing larger FW salmon that can then be induced to undergo smoltification before transfer into marine net pens for grow‐out and harvest.
Le Thi Hong Gam, Daniel W. Montgomery, Daniel S. Laronde, Rachael Mackinnon, Jeffrey G. Richards, Colin J. Brauner   +5 more
wiley   +1 more source

New Isocoumarins from the Marine Fungus Phaeosphaeriopsis sp. WP-26. [PDF]

Mar Drugs, 2023
Wang P, Wang H, Yang J, Yang L, Cai C, Yuan J, Wu F, Gai C, Mei W, Dai H.   +9 more
europepmc   +1 more source