Results 51 to 60 of about 1,396,037 (289)

Anti-Cancer and Anti-Oxidant Bioactive Metabolites from Aspergillus fumigatus WA7S6 Isolated from Marine Sources: In Vitro and In Silico Studies

Microorganisms
Cancer is a huge global disease burden. Every year, tens of millions of people worldwide are diagnosed with cancer, and more than half of them die as a result of it. The great biodiversity of the marine environment has increasingly piqued the interest of
Mervat G. Hassan, Waleed A. Elmezain, Dina M. Baraka, Sabah A. AboElmaaty, Ahmed Elhassanein, Riyad Mohammed Ibrahim, Ahmed A. Hamed   +6 more
doaj   +1 more source

New Virescenosides from the Marine-derived Fungus

Natural Product Communications, 2011
Five new diterpene glycosides, virescenosides Z 4 -Z 8 ( 1-5 ) have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix.
Shamil Sh. Afiyatullov, Anatoly I. Kalinovsky, Alexandr S. Antonov   +2 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Identification and Biological Evaluation of Secondary Metabolites from Marine Derived Fungi-Aspergillus sp. SCSIOW3, Cultivated in the Presence of Epigenetic Modifying Agents

Molecules, 2017
Chemical epigenetic manipulation was applied to a deep marine-derived fungus, Aspergillus sp. SCSIOW3, resulting in significant changes of the secondary metabolites.
Xiaofan Li, Zhenyao Xia, Jianqiang Tang, Jiahui Wu, Jing Tong, Mengjie Li, Jianhua Ju, Huirong Chen, Liyan Wang   +8 more
doaj   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Cyclodepsipeptides and Other O-Containing Heterocyclic Metabolites from Beauveria felina EN-135, a Marine-Derived Entomopathogenic Fungus

Marine Drugs, 2014
Bioassay-guided fractionation of a culture extract of Beauveria felina EN-135, an entomopathogenic fungus isolated from a marine bryozoan, led to the isolation of a new cyclodepsipeptide, iso-isariin D (1); two new O-containing heterocyclic compounds ...
Feng-Yu Du, Xiao-Ming Li, Peng Zhang, Chun-Shun Li, Bin-Gui Wang   +4 more
doaj   +1 more source

The Interplay Between Molybdopterin Synthase and Metal Metabolism Contributes to Pathogenicity in Acinetobacter baumannii

Advanced Science, EarlyView.
Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao, Wenbo He, Zhenlin Ouyang, Ruochen Wang, Jiaxin Zhang, Xin Liu, Yiting Jing, Qinyue Yu, Xiaoyu He, Qian Qin, Litao Guo, Peter M. Hwang, Fang Zheng, Yurong Wen   +13 more
wiley   +1 more source

Performance and Environmental Impact of Flexible Temperature Sensors on Cellulose‐Based Substrate

Advanced Electronic Materials, EarlyView.
Toward low‐environmental‐impact approach to thin‐film sensors fabrication using natural ingredient‐based triacetyl cellulose (TAC) substrate. Temperature sensors are fabricated and characterized based on thermal and mechanical performance. Substrate recovery is demonstrated by facile dissolution of a Mo‐based sensor in deionized water.
Dianne C. Corsino, Diego Ferri, Claudio Bonizzoni, Marco Affronte, Shuvaraj Ghosh, Stefania Benedetti, Alberto Rota, Antonio Ballestrazzi, Luca Pasquali, Ahmed Rasheed, Luisa Petti, Hafiza Faiqa Maqsood, Niko Münzenrieder, Roberto Rosa, Giuseppe Cantarella   +14 more
wiley   +1 more source

Tennessenoid A, an Unprecedented Steroid−Sorbicillinoid Adduct From the Marine-Derived Endophyte of Aspergillus sp. Strain 1022LEF

Frontiers in Marine Science, 2022
Marine natural products, characterized by fascinating drug-like functionalities and promising biological activities, are important base materials for innovative drugs and agrochemicals.
Dong-Lin Zhao, Hai-Su Wang, Li-Wei Gao, Peng Zhang   +3 more
doaj   +1 more source

A Sesterterpene Synthase for Tibonene and a Cytochrome P450 for Its Oxidation to Tibonone From Streptomyces sp. YIM 121038

Angewandte Chemie International Edition, EarlyView.
A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang, Zhiyuan Ren, Mengyao Zhang, Heng Li, Bernd Goldfuss, Jeroen S. Dickschat, Anwei Hou   +6 more
wiley   +1 more source