Exploring marine toxins: comparative analysis of chemical reactivity properties and potential for drug discovery [PDF]
Frontiers in Chemistry, 2023 Marine toxins, produced by various marine microorganisms, pose significant risks to both marine ecosystems and human health. Understanding their diverse structures and properties is crucial for effective mitigation and exploration of their potential as ...
Norma Flores-Holguín +4 more
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Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins [PDF]
Marine Drugs, 2021 Voltage-gated sodium channels (VGSCs) are considered to be one of the most important ion channels given their remarkable physiological role. VGSCs constitute a family of large transmembrane proteins that allow transmission, generation, and propagation of
Rawan Mackieh +6 more
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Emergent marine toxins risk assessment using molecular and chemical approaches [PDF]
EFSA Journal, 2022 Cyanobacteria harmful blooms represent a deviation to the normal equilibrium in planktonic communities involving a rapid and uncontrolled growth. Owing to the capacity to produce toxins as secondary metabolites, cyanobacteria may cause huge economic ...
Y García‐Cazorla, V Vasconcelos
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Marine Toxins Targeting Kv1 Channels: Pharmacological Tools and Therapeutic Scaffolds [PDF]
Marine Drugs, 2020 Toxins from marine animals provide molecular tools for the study of many ion channels, including mammalian voltage-gated potassium channels of the Kv1 family.
Rocio K. Finol-Urdaneta +5 more
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Extended Targeted and Non-Targeted Strategies for the Analysis of Marine Toxins in Mussels and Oysters by (LC-HRMS) [PDF]
Toxins, 2018 When considering the geographical expansion of marine toxins, the emergence of new toxins and the associated risk for human health, there is urgent need for versatile and efficient analytical methods that are able to detect a range, as wide as possible ...
Inès Dom +5 more
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Marine Toxins as Pharmaceutical Treasure Troves: A Focus on Saxitoxin Derivatives from a Computational Point of View [PDF]
MoleculesThis work highlights the significant potential of marine toxins, particularly saxitoxin (STX) and its derivatives, in the exploration of novel pharmaceuticals.
Norma Flores-Holguín +4 more
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The Incidence of Marine Toxins and the Associated Seafood Poisoning Episodes in the African Countries of the Indian Ocean and the Red Sea [PDF]
Toxins, 2019 The occurrence of Harmful Algal Blooms (HABs) and bacteria can be one of the great threats to public health due to their ability to produce marine toxins (MTs).
Isidro José Tamele +2 more
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How Safe Is Safe for Marine Toxins Monitoring? [PDF]
Toxins, 2016 Current regulation for marine toxins requires a monitoring method based on mass spectrometric analysis. This method is pre-targeted, hence after searching for pre-assigned masses, it identifies those compounds that were pre-defined with available ...
Luis M. Botana +5 more
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Computational Studies of Marine Toxins Targeting Ion Channels [PDF]
Marine Drugs, 2013 Toxins from marine animals offer novel drug leads for treatment of diseases involving ion channels. Computational methods could be very helpful in this endeavour in several ways, e.g., (i) constructing accurate models of the channel-toxin complexes using
Serdar Kuyucak +2 more
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Antioxidants, 2022 Saxitoxin (STX) group toxins consist of a set of analogues which are produced by harmful algal blooms (HABs). During a HAB, filter-feeding marine organisms accumulate the dinoflagellates and concentrate the toxins in the tissues.
Javiera Oyaneder-Terrazas +3 more
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