Results 91 to 100 of about 451 (213)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

GÊNERO, TRAJETORIAS SOCIAS E INTERSECCIONALIDADES: debates políticos contemporâneos tecidos na realidade brasileira

Revista de Políticas Públicas, 2020
The proposal is to problematize social spaces that embody and reproduce the socially constructed place of women linked to the concepts of subordination and subordination.
Ingrid Lorena da Silva Leite, Jessica Monaliza Saraiva Menezes, Gabriela Vieira Rebouças, Jéssica Silva de Sousa, Liniane de Cássia Santos   +4 more
doaj  

Local Indicators of Mark Association for Marked Spatial Point Processes

Journal of Computational and Graphical Statistics
Distinct local mark behaviors are increasingly observed in applications of marked spatial point processes. These local differences reveal important limitations of global mark correlation functions, which can fail to identify true mark associations when some mark behaviors dominate others. In this paper, we introduce a family of local indicators of mark
Matthias Eckardt, Mehdi Moradi
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Temporal adaptive neural ordinary differential equations with deep spatio-temporal point processes for real-time network intrusion detection

Complex & Intelligent Systems
Network attacks exploit complex temporal dependencies spanning microseconds to months, requiring unified modelling of continuous system dynamics and discrete event occurrences.
Roger Nick Anaedevha, Alexander Gennadievich Trofimov, Yuri Vladimirovich Borodachev   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Critical approach to the jurist's historical formation in the systems of western Right

Revista MENDIVE, 2012
The jurist's historical formation has been marked by the system of Right in that the curriculum of the career is framed. In occident the Anglo-Saxon system and the Roman - French one prevail, in one the historical contents are nurtured of the judicial ...
Alie Pérez Véliz, Teresa Díaz Domínguez   +1 more
doaj  

Research on the Self-Organized Criticality and Fracture Predictability of Sandstone via Real-Time CT Scanning and AE Monitoring

Applied Sciences
Progressive damage evolution in rock masses serves as the fundamental mechanism driving geological hazards by controlling deformation patterns and failure predictability. To address the critical challenge of predicting fracture behaviors in heterogeneous
Huimin Yang, Yongjun Song, Jianxi Ren, Yiqian Chen   +3 more
doaj   +1 more source

Transaction component of exogenous factors of influence upon employment under conditions of globalisation of economy [PDF]

Problemi Ekonomiki, 2013
The goal of the article lies in identification of influence of globalisation upon efficiency of financial and loan instruments that ensure regulation and stimulation of employment and the role of transaction costs in these processes. To achieve the goal,
Glushach Anna V., Arkhiyeryeev Sergey I.
doaj