Results 101 to 110 of about 270,114 (335)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Validity Control of Markers Used in Molecular Marker Assisted Selection in Tomato
Yüzüncü Yıl Üniversitesi Tarim Bilimleri Dergisi, 2022 This study aimed to check the validity of the SCAR and CAPS markers developed for certain diseases and pests on some tomato cultivars and genotypes in molecular marker-assisted selection.
Ceylan Pınar UÇAR, Suat ŞENSOY
doaj +1 more source
Economic Analysis of Marker-Assisted Selection in Canola [PDF]
Replaced with revised version of poster 07/19/11.Production Economics, Productivity Analysis, Research and Development/Tech Change/Emerging Technologies,
Naseem, Anwar, Singla, Rohit
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Electronic Journal of Plant Breeding, 2018 Bacterial blight (BB) of rice caused by the pathogen Xanthomonas oryzae pv. oryzae and the insect gall midge (GM) (Orseolia oryzae) are two major limitations of rice production.
Krishnakumar R and, N. Kumaravadivel
doaj +1 more source
Association Mapping for Common Bunt Resistance in Wheat [PDF]
, 2013 Common bunt, caused by Tilletia caries and T. foetida, is a fungal disease of wheat world wide. Infection, occurring via seed borne teliospores, is generally controlled by the application of seed treatments prior to sowing.
Backes, Gunter +3 more
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Knowledge database assisted gene marker selection for chronic lymphocytic leukemia
Journal of International Medical Research, 2018 Objective To investigate whether previously curated chronic lymphocytic leukemia (CLL) risk genes could be leveraged in gene marker selection for the diagnosis and prediction of CLL.
Xixi Xiang +3 more
doaj +1 more source
Improving stress coping ability: comparison between the CYP17 genotype Of Ovis Aries and Capra Hircus [PDF]
, 2010 The ability of animals to adapt to stress is not only an animal health and welfare concern, but also influences reproduction potential and robustness. An important pathway involved in the stress response is the hypothalamic-pituitary-adrenal axis (HPAA ...
Cloete, S.W.P. +3 more
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source