Results 81 to 90 of about 4,652,084 (286)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Biotechnology in Animal Husbandry, 2011 Because of insulin-like growth factor-I (IGF-I) gene plays an important regulatory function in milk secretion in cattle, IGF1 gene is potential quantitative trait locus and genetic marker (i.e, SNP) associated with milk production trait in cattle.
S.M. Abdel-Rahman +3 more
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Effectiveness of applying different methods of molecular genetics in swine selection (A review)
Животновъдни науки, 2023 The rapid development of molecular genetics in the last two decades, primarily related to the technological breakthrough in the field of genome sequencing of higher organisms, has made it possible to apply new models of work.
Katya Eneva, Apostol Apostolov
doaj
Rice, 2018 Background The brown planthopper (BPH), an insect species that feeds on rice plants (Oryza sativa L.), is one of the most destructive insect pests of rice.
Haichao Jiang +7 more
doaj +1 more source
, 2005 A method of selecting desirable individuals in a breeding scheme based on DNA molecular marker patterns instead of, or in addition to, their trait values. A tool that can help plant breeders select more efficiently for desirable crop traits.
Richardson, Kelley, Byrne, Patrick
core
Marker Assisted Selection: A Novel Approach for Crop Improvement
The process of marker-assisted selection, or marker-aided selection (MAS), selects a trait of interest indirectly by considering a marker linked to the trait (e.g., quality, productivity, disease resistance, and biotic stress tolerance) rather than the ...
Patel, Brijesh +7 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Simulation of marker assisted selection strategies in beef cattle [PDF]
, 2012 Marker-assisted selection (MAS) has been presented as a promising tool for animal breeding, but its application in beef cattle is still very limited. The technology is still expensive and the way to combine molecular information with more traditional ...
Macor, Laura +2 more
core +1 more source