Results 131 to 140 of about 2,805,781 (316)

Scored Rule Sets: A Unified Framework for Interpretable Classification, Regression, and Cluster Explanation

AI
Interpretable machine learning on tabular data has traditionally relied on fragmented rule-induction ecosystems, where distinct paradigms are used for discrete and continuous targets, and transparent post hoc explanation of unsupervised structures is ...
Robin Nunkesser
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Marker-assisted introgression in backcross breeding programs [PDF]

, 1996
The efficiency of marker-assisted introgression in backcross populations derived from inbred lines was investigated by simulation. Background genotypes were simulated assuming that a genetic model of many genes of small effects in coupling phase explains
Visscher, PM, Haley, CS, Visscher, P. M., Thompson, R, Thompson, R., Haley, C. S.   +5 more
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Partnerships and collaboration rebuild communities [PDF]

In Pawtucket, Rhode Island, a university and community partnership used collaborative planning to strengthen a neighborhood. Marcia Marker Feld of the University of Rhode Island describes Woodlawn's Community Outreach Partnership Center Program ...
Marcia Marker Feld
core  

Stress analysis of load conditions in a pre-stressed AISI 304L bolt by high-energy-dispersive X-ray diffraction measurement and FEA

Journal of Materials Research and Technology
This paper investigates the multiaxial stress state in an AISI 304L finish-rolled bolt of a gradually pre-stressed M8 bolt-nut connection in the first load-bearing thread using high-energy-dispersive X-ray diffraction (EDXRD). This thread area is crucial
D. Hinse, K. Pantke, S. Strodick, F. Walther   +3 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Captain Robert Gray historical marker

, 2013
Title from PDF caption (viewed on January 25, 2017)."Ribbon cutting ceremony, Thursday, September 12, 2013, 11:00 a.m., Tillamook Bay Wayside, US Highway 101."Commemorates the updated historical marker about the explorer Robert Gray, including the ...

core  

METABOLITES OF NITRIC OXIDE AS A MARKER OF THE SYNDROME OF ACUTE LUNG INJURY SYNDROME IN NEWBORNS

, 2018
METABOLITES OF NITRIC OXIDE AS A MARKER OF THE SYNDROME OF ACUTE LUNG INJURY SYNDROME IN ...
O.H. Buriak, N.D. Pavliukovych, O.V. Pavliukovych, V.V. Komarnitskiy   +3 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source