Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Quantitative Evaluation of OpenCV Visual Tracking Algorithms for Drawn Markers Under Dynamic Facial Deformation. [PDF]
Sensors (Basel)Tkaczyk K, Sitnik R.
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Case Mix and Protocol Constraints in Diagnostic Language Model Conversations: A Secondary Analysis of Released MedR-Bench Outputs. [PDF]
CureusLi OM, Li SXT, Li Y.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Marker-Free Isoelectric Focusing Patterns for Identification of Meat Samples via Deep Learning
Isoelectric focusing (IEF) is a powerful tool for resolving complex protein samples, which generates IEF patterns consisting of multiplex analyte bands.
Yiren Cao (9104240) +9 more
core +1 more source
Genome-Wide Marker-Trait Analysis of Agronomic and Biomass-Related Traits in an Interspecific Miscanthus F<sub>1</sub> Population Grown on Reclaimed Mine Land. [PDF]
Plants (Basel)Xiao L +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A chromosome-level genome assembly of an elite indica breeding line resolves the genomic architecture of drought-yield QTLs qDTY<sub>2.2</sub> and qDTY<sub>4.1</sub> in rice. [PDF]
Plant GenomeHan JH +6 more
europepmc +1 more source