Results 41 to 50 of about 3,952,373 (303)

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Horowski, Das Europa der Könige (Rowohlt, 2018)

open access: yesRoyal Studies Journal, 2020
Review of Leonhard Horowski, Das Europa der Könige (Hamburg: Rowohlt, 2018).
Juliane Märker
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul   +13 more
wiley   +1 more source

Ganzheitliche nutzungs- und kostenoptimierte Hochschulbauplanung

open access: yesZeitschrift für Hochschulentwicklung, 2012
Der Beitrag beschreibt den Aufbau einer neuen Hochschule von der ersten Idee, der Gründung über die Genehmigungsphase, den Architekturwettbewerb, die anschließende Planungsphase bis hin zur Realisierung.
Karl-Heinz Sandknop
doaj   +1 more source

A Hierarchical Optimization Method for the Design of Active Hybrid Structures

open access: yesFrontiers in Built Environment, 2022
In structural engineering, active structures that combine the principles of lightweight construction with bending elastic component behavior are increasingly being investigated. For the realization of a prototype of an active hybrid roof structure at the
Paul Marker, Achim Bleicher
doaj   +1 more source

What Makes a Marker a Good Marker? [PDF]

open access: yesBrain, Behavior and Evolution, 2014
To validate if DCX truly predicts neuron recruitment throughout the canary brain, it should correlate to a high degree with established methods for studying neuron recruitment, such as labeling cells with the mitotic marker 5-bromo-2-deoxyuridine (BrdU).
Vellema, M.   +3 more
openaire   +2 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle   +5 more
wiley   +1 more source

The rise of ergativity in Hindi: assessing the role of grammaticalization [PDF]

open access: yes, 2009
This article investigates the origins and development of the ergative patterning in Hindi. Following traditional Indo-Aryan scholarship, two evolutions are discerned: (i) the reanalysis of a passive as an ergative construction, and (ii) the development ...
De Cuypere, Ludovic, Verbeke, Saartje
core   +1 more source

Surrogate Markers for Cardiovascular Disease [PDF]

open access: yesCirculation, 2004
Pignoli et al1 validated the concept that intima-media thickness (IMT), as measured by B-mode ultrasound and applied either in vitro or in situ at the time of autopsy, reflected direct measurements of aortic and/or carotid specimens. Values obtained by ultrasound at autopsy and by direct measurement were similar to those obtained from living subjects ...
Dahlöf, B. (Björn)   +2 more
openaire   +3 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel   +3 more
wiley   +1 more source

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