Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Novel DNA methylation biomarkers in urine for non-invasive diagnosis of bladder urothelial carcinoma. [PDF]
Shi C +7 more
europepmc +1 more source
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Comparison of inflammatory markers and microflora in cirrhotic patients with portal vein thrombosis: a retrospective study. [PDF]
Sun Y +6 more
europepmc +1 more source
Construction and validation of a prediction model for cystitis glandularis using serological markers combined with histological indexes to predict recurrence risk. [PDF]
Wang Y +6 more
europepmc +1 more source
Meta-analysis of the effects of probiotic supplementation on bone turnover markers in middle-aged and elderly patients with osteoporosis. [PDF]
Yuan Y, Li J, Wang K, Li J, Wei H.
europepmc +1 more source
Updated resource of 180K soybean SNP genotyping array based on the T2T reference genome. [PDF]
Hwang JH, Lee S, Lee JS, Kim KD.
europepmc +1 more source
Transcriptomic Profile of Directed Differentiation of iPSCs into Hepatocyte-like Cells. [PDF]
Panchuk I +7 more
europepmc +1 more source

