Results 41 to 50 of about 14,128,135 (294)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Cost-utility Analysis of Home Mechanical Ventilation Compared to Hospital Settings in Patients with Amyotrophic Lateral Sclerosis

open access: yesCurrent Directions in Biomedical Engineering, 2022
Amyotrophic lateral sclerosis is a progressive neuromuscular disease. Mechanical ventilation delays death and use at home can reduce costs and increase quality of life.
Gajdoš Ondřej   +3 more
doaj   +1 more source

Monotonicity in Markov models

open access: yes, 2023
Published by RWTH Aachen University ...
openaire   +2 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Torpedo performance Markov model

open access: yes, 2016
The improved evasive capability of the modern deiseal submarine can downgrade the performance of a torpedo seriously. However, a few studies have concerned the sophisticate diesel submarine as a main factor for the influence of a torpedo's attack.
Hui, Lin; 惠霖; Wang, Kuei Min
core   +1 more source

A coupled hidden Markov model for disease interactions [PDF]

open access: yes, 2012
To investigate interactions between parasite species in a host, a population of field voles was studied longitudinally, with presence or absence of six different parasites measured repeatedly.
Telfer, S.E.   +11 more
core   +1 more source

CluM: A Clustering–Cum–Markov model for resource prediction in a data center

open access: yesInternational Journal of Applied Mathematics and Computer Science
High-end data centers are required to process the user requests and provide them with a better quality of service. The prominent issues in building a sustainable data center are reduced carbon footprint, dynamic capacity planning to reduce resource ...
Govindarajan Madhupriya   +2 more
doaj   +1 more source

Cost-Effectiveness Analysis of Maintenance Olaparib in Patients with Metastatic Pancreatic Cancer and a Germline BRCA1/2 Mutation Based on the POLO Trial

open access: yesCancer Management and Research, 2020
Mei Zhan,1– 3 Hanrui Zheng,1– 3 Yu Yang,2,4 Zhiyao He,1 Ting Xu,1,3 Qiu Li2,4 1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2West China Biomedical Big Data Center, Sichuan ...
Zhan M   +5 more
doaj  

Analysis Results of the Regional Registry of Patients with Diffuse Large B-cell Lymphoma: Risk Factors and Chemo-Immunotherapy Issues

open access: yesКлиническая онкогематология, 2019
Background & Aims. At least one third of patients with diffuse large B-cell lymphoma (DLBCL) are resistant to first-line therapy. R-CHOP chemo-immunotherapy does not yield acceptable results in high-risk patients. Effectiveness of options based either on
Kamil’ Daniyalovich Kaplanov   +11 more
doaj   +1 more source

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