Results 61 to 70 of about 254,480 (307)

Identification via Numerical Computation of Transcriptional Determinants of a Cell Phenotype Decision Making

Frontiers in Genetics, 2019
Complex cellular processes, such as phenotype decision making, are exceedingly difficult to analyze experimentally, due to the multiple-layer regulation of gene expression and the intercellular variability referred to as biological noise.
Marilisa Cortesi, Alice Pasini, Simone Furini, Emanuele Giordano, Emanuele Giordano, Emanuele Giordano   +5 more
doaj   +1 more source

Compositional Approximate Markov Chain Aggregation for PEPA Models [PDF]

, 2012
Approximate Markov chain aggregation involves the construction of a smaller Markov chain that approximates the behaviour of a given chain. We discuss two different approaches to obtain a nearly optimal partition of the state-space, based on different ...
Dimitrios Milios, Stephen Gilmore, Milios, Dimitrios, Gilmore, Stephen; id_orcid   +3 more
core   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

Model-based cost-effectiveness analysis of atorvastatin drugs for prevention of cardiovascular diseases in Iran

International Journal of Preventive Medicine, 2020
Background: Today, cardiovascular disease is one of the main causes of mortality and disability in most developed and developing countries. The prediction of the major causes of deaths all over the world at all ages shows that 61% of deaths are due to ...
Alireza Jabbari, Abdosaleh Jafari, Marziye Hadian, Mohammad Ghasemi   +3 more
doaj   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Impact analysis of expanded access to ketamine for treatment-resistant depression

Journal of Comparative Effectiveness Research
Aim: This study aimed to estimate the economic impacts of expanded access to ketamine relative to electroconvulsive therapy (ECT) by offering intravenous ketamine to US patients with nonpsychotic treatment-resistant depression (TRD) and moderate-to ...
Thanh Lu, Sophia D’Angelo, Zohra Tayebali, Matthew Dempsey, Kristen Giombi, Olga Khavjou   +5 more
doaj   +1 more source

MGDP: Mastering a Generalized Depth Perception Model for Quadruped Locomotion

Advanced Science, EarlyView.
ABSTRACT Perception‐based Deep Reinforcement Learning (DRL) controllers demonstrate impressive performance on challenging terrains. However, existing controllers still face core limitations, struggling to achieve both terrain generality and platform transferability, and are constrained by high computational overhead and sensitivity to sensor noise.
Yinzhao Dong, Ji Ma, Yidan Lu, Jiahui Zhang, Wanyue Li, Yeke Chen, Teng Zhang, Xuechao Chen, Zhangguo Yu, Peng Lu   +9 more
wiley   +1 more source

Ultra‐Wide‐Field Noninvasive Imaging Through Scattering Media Via Physics‐Guided Deep Learning

Advanced Science, EarlyView.
We propose a physics‐guided adaptive dual‐domain learning method for ultra‐wide‐field noninvasive imaging through scattering media, namely UNI‐Net. Our method not only reduces the requirement for real experimental data by an order of magnitude but also enables clear imaging of complex scenes with an ultra‐large field of view, which is 164 times the OME
Lintao Peng, Mingwei He, Jeff Zhu, Sujit K. Sahoo, Liheng Bian, Cuong Dang   +5 more
wiley   +1 more source

Churn Prediction in Iran Banking Industry Case of a Private Iranian Bank [PDF]

پژوهش‌های مدیریت عمومی, 2018
After the emergence of private banks in Iran, due to its attractiveness, this industry has witnessed a rapid growth such banks. The abundance of private banks led to a very high pressure competitive environment and gave dissatisfied customers a chance to
Mohsen Asgari, Mohammadreza Taghva, Mohammadtaghi Taghavifard   +2 more
doaj   +1 more source