Results 71 to 80 of about 21,998,513 (385)
Frontiers in Pharmacology, 2022 Objective: Pembrolizumab plus chemotherapy is recommended as the first-line treatment for advanced oesophageal cancer. The objective of this study is to evaluate the cost-effectiveness of pembrolizumab plus chemotherapy as first-line therapy for advanced
Meiyu Wu +16 more
doaj +1 more source
International Journal of Adaptive Control and Signal Processing, EarlyView.The cost as a function of the number of experiments for a non‐symmetric 21×21$$ 21\times 21 $$ system. Four approaches are shown: the proposed stochastic conjugate gradient ILC (SCGILC) method (), deterministic conjugate gradient ILC (), stochastic gradient descent ILC () and deterministic gradient descent ILC ().
Leontine Aarnoudse, Tom Oomen
wiley +1 more source
Markov Models in health care [PDF]
Einstein (São Paulo), 2010 ABSTRACT Markov Chains provide support for problems involving decision on uncertainties through a continuous period of time. The greater availability and access to processing power through computers allow that these models can be used more often to represent clinical structures. Markov models consider the patients in a discrete state of health, and the
Sato, Renato Cesar +1 more
openaire +7 more sources
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
International Journal of COPD, 2022 Ming Hu,1,* Pan Ding,1,* Jinfang Ma,2 Nan Yang,1 Jinping Zheng,2 Naitong Zhou1 1West China School of Pharmacy Sichuan University, Chengdu, People’s Republic of China; 2State Key Laboratory of Respiratory Disease, National Clinical Research Center
Hu M +5 more
doaj
Economic evaluation of the chronic hepatitis B treatment strategies in Italy
Farmeconomia: Health Economics and Therapeutic Pathways, 2013 BACKGROUND AND OBJECTIVE: Pharmacological approaches available in chronic hepatitis B (CHB) are based on 48-weeks finite course of peg-interferon (PEG-IFN) or continuous administration of nucleoside analogues.
Sergio Iannazzo +6 more
doaj +1 more source
Hidden Markov model speed heuristic and iterative HMM search procedure
BMC Bioinformatics, 2010 BackgroundProfile hidden Markov models (profile-HMMs) are sensitive tools for remote protein homology detection, but the main scoring algorithms, Viterbi or Forward, require considerable time to search large sequence databases.ResultsWe have designed a ...
Steve L. Johnson +2 more
semanticscholar +1 more source
Markov-modulated generalized Ornstein-Uhlenbeck processes and an application in risk theory [PDF]
arXiv, 2020 We derive the Markov-modulated generalized Ornstein-Uhlenbeck process by embedding a Markov-modulated random recurrence equation in continuous time. The obtained process turns out to be the unique solution of a certain stochastic differential equation driven by a bivariate Markov-additive process.
arxiv
Approximating the Markov Chain of the Curie-Weiss Model [PDF]
arXiv, 2021 In this paper, we quantify some known approximation to the Curie-Weiss model via applying the Stein method to the Markov chain whose stationary distribution coincides with Curie-Weiss model.
arxiv
Interfacial Yield Stress Response in Synthetic Mucin Solutions
Advanced Materials Interfaces, EarlyView.The solution rheology of novel synthetic mucins mimicking natural mucin domains is studied. Like many natural mucin solutions, apparent solid‐like rheology is seen. However, no bulk structural features are found to explain it. Interfacial rheology and robust modelling reveal that this arises from molecular associations at the air–water interface ...
Sumit Sunil Kumar +7 more
wiley +1 more source