Results 121 to 130 of about 575,581 (334)

Risk‐aware safe reinforcement learning for control of stochastic linear systems

open access: yesAsian Journal of Control, EarlyView.
Abstract This paper presents a risk‐aware safe reinforcement learning (RL) control design for stochastic discrete‐time linear systems. Rather than using a safety certifier to myopically intervene with the RL controller, a risk‐informed safe controller is also learned besides the RL controller, and the RL and safe controllers are combined together ...
Babak Esmaeili   +2 more
wiley   +1 more source

Regional Shopping Objectives in British Grocery Retail Transactions Using Segmented Topic Models

open access: yesApplied Stochastic Models in Business and Industry, EarlyView.
ABSTRACT Understanding the customer behaviours behind transactional data has high commercial value in the grocery retail industry. Customers generate millions of transactions every day, choosing and buying products to satisfy specific shopping needs.
Mariflor Vega Carrasco   +4 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

open access: yesHepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim   +12 more
wiley   +1 more source

The functional model of stage access to a separate computer hardware in the process of a virus attack in computer systems

open access: yesИзвестия высших учебных заведений. Поволжский регион:Технические науки
Background. Increasing the adequacy of mathematical models of the impact of malicious software (MS), used to substantiate the requirements for the characteristics and directions for improving the anti-virus mechanisms of computer systems (CS), can be ...
R.A. Khvorov   +5 more
doaj   +1 more source

Stochastic models of population growth

open access: yesMathematical Biosciences and Engineering
We considered three types of stochastic models of a single population growth: with diffusion-type noise; with parameters replaced by stochastic processes; and with random jumps describing a sudden decrease in population size.
Katarzyna Pichór, Ryszard Rudnicki
doaj   +1 more source

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić   +4 more
wiley   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet   +17 more
wiley   +1 more source

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