Advanced Science, EarlyView.SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang +8 more
wiley +1 more source
A Novel System Reliability Modeling of Hardware, Software, and Interactions of Hardware and Software
Mathematics, 2019 In the past few decades, a great number of hardware and software reliability models have been proposed to address hardware failures in hardware subsystems and software failures in software subsystems, respectively.
Mengmeng Zhu, Hoang Pham
doaj +1 more source
Excursions of a Markov Process
The Annals of Probability, 1979 The excursion straddling $t$ and the first excursion exceeding $u$ in length of a Markov process are compared in a general setting. These results are then specialized to the excursions from a point, and to specific processes. The main tool is the general theory of excursions as developed by Maisonneuve and others.
openaire +2 more sources
PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes
Advanced Science, EarlyView.A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li +10 more
wiley +1 more source
Reversible Markov decision processes and the Gaussian free field [PDF]
, 2022 Venkat Anantharam
openalex +1 more source
Full‐Stack Architectures for Intelligent Brain‐Computer Interfaces
Advanced Science, EarlyView.System‐level overview of brain–computer interfaces (BCIs), illustrating the integration of neural signal acquisition, wireless transmission, and adaptive decoding. Advanced electrode, tissue interfaces, energy‐efficient communication, and robust algorithms collectively enable stable signal quality, real‐time processing, and closed‐loop operation ...
Hee Kyu Lee +9 more
wiley +1 more source
Lie algebraic discussion for affinity based information diffusion in social networks
Open Physics, 2017 In this paper we develop a dynamical information diffusion model which features the affinity of people with information disseminated in social networks.
Shang Yilun
doaj +1 more source
Method of lossless image compression in the Earth remote sensing systems
Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2016 A method of lossless digital image compression is presented in the paper. Its implementation demands minimum computing resources and it can be efficiently used in Earth remote sensing systems.
E. P. Petrov +2 more
doaj +1 more source
Correction to: Random Coefficient Autoregressive Processes: a Markov Chain Analysis of Stationarity and Finiteness of Moments by Paul D. Feigin and Richard L. Tweedie J. Time Series Anal., Vol. 6, No. 1 (1985) [PDF]
, 2020 Paul D. Feigin
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PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression
Advanced Science, EarlyView.Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian +13 more
wiley +1 more source