Results 101 to 110 of about 980,269 (324)

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Synthetic Biology for Terraformation Lessons from Mars, Earth, and the Microbiome

open access: yesLife, 2020
What is the potential for synthetic biology as a way of engineering, on a large scale, complex ecosystems? Can it be used to change endangered ecological communities and rescue them to prevent their collapse?
Nuria Conde-Pueyo   +6 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Amazing Space: Mars 2003--Closest Approach Lithograph [PDF]

open access: yes, 2003
This lithograph features two images of Mars, taken 11 hours apart with NASA's Hubble Space Telescope, which reveal two nearly opposite sides of Mars.

core  

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Life on Mars [PDF]

open access: yesNature, 1908
IF the canals of Mars are structures made by intelligent beings, it is difficult to believe that these beings have not at their disposal appliances both for construction and survey. It is difficult to believe that some of these appliances are not made of metal. If made of metal, it is difficult to believe that the Martians do not use fire.
openaire   +3 more sources

On marginally outer trapped surfaces in stationary and static spacetimes

open access: yes, 2007
In this paper we prove that for any spacelike hypersurface containing an untrapped barrier in a stationary spacetime satisfying the null energy condition, any marginally outer trapped surface cannot lie in the exterior region where the stationary Killing
Alberto Carrasco   +14 more
core   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Nitrogen and phosphorus recovery from hemodialysis wastewater to use as an agricultural fertilizer

open access: yesNefrología, 2023
Introduction: Hemodialysis wastewater contains high concentrations of ammonia nitrogen and phosphorus. Recovery of these nutrients as soil fertilizers represents an interesting opportunity to ensure a sustainable fertilizer supply. Methods: In this paper,
Faissal Tarrass   +2 more
doaj  

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