Results 121 to 130 of about 473,493 (245)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

2011 MARS Refresher Presentation (2 of 3)

, 2011
Information sessions that shall outline the general principles of the 2011 annual Merit, Appraisal and Recognition Scheme (MARS). Presentation will be given in English.
Thiede, Gabriele, Morris, Ariana
core  

Global evidence on molecular adsorbent recirculating system uses for trauma-induced acute liver failure: A scoping review. [PDF]

World J Crit Care Med
Ribeiro Junior MAF, Dib Possiedi R, Thalib HI, Fontenelle Vieira L, Teeter WA, Scalea TM.   +5 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

2010 MARS Refresher Presentation (3 of 3)

, 2010
Information sessions that shall outline the general principles of the 2010 annual Merit, Appraisal and Recognition Scheme (MARS).
Thiede, Gabriele, Morris, Ariana
core  

Metal artifact reduction sequence MRI in hip periprosthetic joint infection management : a noninvasive reference for infection control before two-stage reimplantation. [PDF]

Bone Joint Res
Lin Z, Lin L, Liu M, Zhang C, Zhang W, Chen Y, Wu C, Huang Z, Guan Z, Fang X.   +9 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Chronic pain and mobile health: Are the apps that occupational therapists recommend of high quality? [PDF]

Aust Occup Ther J
Smith J, Tran T, Hunt J, Liddiard K.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Brief von John Mars an Kurt Rothschild

BRIEF VON JOHN MARS AN KURT ROTHSCHILD Brief von John Mars an Kurt Rothschild ([1]
Mars, John
core   +1 more source