Results 141 to 150 of about 473,493 (245)

Multivariate adaptive regression spline modeling for estimating carotid artery plaque thickness in Chinese men with type 2 diabetes. [PDF]

J Int Med Res
Yang CC, Hsu CY, Pei D, Chu TW, Liang YJ, Leu JG.   +5 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Real-World Medication Adherence and Medication Reviews in Adults and Children With Cystic Fibrosis. [PDF]

Pediatr Pulmonol
Roeke L, van de Ven LI, Vonk SEM, Coremans JJM, Dompeling E, Bannier MAGE, Karapinar-Çarkit F, Dalem JR.   +7 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

29.70 S91-32389 Mars through Hubble

A series of images of Mar.

core  

Induced magnetosphere of Mars responds fast to interplanetary magnetic field rotation. [PDF]

Nat Commun
Lin R, Zhou J, Huang S, Yuan Z, Wang Y, Wu H, Jiang K, Xu S, Zou Z, Su Z, Zhang T, Dong Y, Xiong Q, Huang H.   +13 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Deep drilling on Mars: pneumatic chip clearing model for the RedWater mining system. [PDF]

Space Planet Resour
Stolov L, Palmowski J, Zacny K, Yen B, Mellerowicz B, Mank Z, Sanasarian L, Schultz J.   +7 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Plasma acceleration and boundary compression in the magnetosheath of Mars under low-Alfvén-Mach-number solar wind. [PDF]

Nat Commun
Qiao F, Li L, Xu Q, Xie L, Zhang Y, Kong L, Tang B, Li W, Gou X, Wang J, Zhou B, Feng Y, Holmström M, Williamson H, Wang XD, Zhang A, Wang L, Jin T, Ma J, Sun F, Wang M.   +20 more
europepmc   +1 more source