Results 121 to 130 of about 1,068,414 (309)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Landform detection on Mars using image segmentation with a u-net convolutional neural network architecture

, 2023
Florian Auer-Welsbach, Andreas Windisch, Giacomo Nodjoumi   +2 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Controlled photomosaic of the MTM 40317 Quadrangle, northern Arabia region of Mars [PDF]

, 1993
U.S. Geological Survey
openalex   +1 more source

High-resolution nesting simulations for the EDL stage of China’s first Mars exploration mission (Tianwen-1)

, 2023
Jing Xiao, Kim‐Chiu Chow, Shaojie Qu, Yanqi Hu, Haogong Wei, Yemeng Wang, Kun Zhang   +6 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Detecting unknown intrusions from large heterogeneous data through ensemble learning

Intelligent Systems with Applications
The rapid expansion of data volumes, technological advancements, and the emergence of the Internet of Things (IoT) have heightened concerns regarding the detection of unknown intrusions based on singular sources of network traffic.
Farah Jemili, Khaled Jouini, Ouajdi Korbaa   +2 more
doaj   +1 more source

Controlled photomosaic of part of the Elysium Mons region of Mars [PDF]

, 1986
U.S. Geological Survey
openalex   +1 more source

Mars Sample Return Rock Sampling: Post-landing Extraction of Solid-core Samples.

, 2023
J. C. Bridges, F. Thiessen, NASA-ESA MSR Rock Sampling Team   +2 more
openalex   +1 more source

Quick trips to Mars [PDF]

The design of a Mars Mission Vehicle that would have to be launched by two very heavy lift launch vehicles is described along with plans for a mission to Mars.
Hornung, R.
core   +1 more source