Results 131 to 140 of about 994,793 (297)

Mars: A reassessment of its interest to biology [PDF]

Of all the planets in the solar system, Mars is certainly the one that has inspired the most speculation concerning extraterrestrial life. Observers had long ago noticed that Mars exhibits changes in its polar caps and alterations in its surface ...
Mckay, Christopher P.
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Evaluating the biosignature potential of ammonium in Proterozoic red beds and implications for the search for life on Mars

Earth and Planetary Physics
Over the past two decades, it has become increasingly apparent that early Mars may once have been warmer, wetter and more habitable for microbial life than it is today, which has spurred discussions about potential biosignatures that may be preserved in ...
Eva E. Stüeken, Philip Fralick, Stephen Hillier, Anthony R. Prave   +3 more
doaj   +1 more source

The Willing of Humans to Settle on Mars, and the Factors that Affect it

, 2022
Savyan Aggarwal, Himani Rathore
openalex   +2 more sources

Mars [PDF]

Nature, 1874
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Mineral paragenesis on Mars: The roles of reactive surface area and diffusion [PDF]

, 2017
Alberto González Fairén, Carolina Gil‐Lozano, Esther R. Uceda, E. Losa-Adams, Alfonso F. Dávila, L. Gago-Duport   +5 more
openalex   +1 more source

Reliable Service -Oriented Architecture for Nasa ’s Mars Exploration Rover Mission

, 2022
Puhiza Iseni, Festim Halili
openalex   +1 more source

Mars [PDF]

Science, 1892
openaire   +3 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source