Results 131 to 140 of about 980,269 (324)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

The Satellites of Mars [PDF]

open access: yesNature, 1877
IT seems worthy of notice that the prophetic genius of Homer has already not only identified but even given names to the two satellites of Mars. I allude, of course, to the passage in the fifteenth book of the Iliad, where Ares is preparing to descend to the earth (possibly this refers to an unusually near approach at opposition, as at the present time)
openaire   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Investigation of risk factors associated with Ancylostoma spp. infection and the benzimidazole F167Y resistance marker polymorphism in dogs from the United States

open access: yesInternational Journal for Parasitology: Drugs and Drug Resistance
Ancylostoma caninum is the most significant intestinal nematode parasite of dogs. We acquired fecal surveillance data from a large population of dogs in the United States (US). A diagnostic test using real-time PCR (qPCR) for Ancylostoma spp.
Pablo D. Jimenez Castro   +7 more
doaj  

Stability of marginally outer trapped surfaces and existence of marginally outer trapped tubes

open access: yes, 2007
The present work extends our short communication Phys. Rev. Lett. 95, 111102 (2005). For smooth marginally outer trapped surfaces (MOTS) in a smooth spacetime we define stability with respect to variations along arbitrary vectors v normal to the MOTS ...
Andersson, Lars   +2 more
core   +1 more source

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