Results 131 to 140 of about 511,111 (317)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Summary of GR15 Session D1(1), Quantum General Relativity [PDF]

open access: yesarXiv, 1998
This summary was prepared for the proceedings of the GR15 conference in Pune, India in Dec. 1997.
arxiv  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Photon Scattering by Negative Energy Electrons [PDF]

open access: yesarXiv, 2002
This paper has been withdrawn due to an error in section 3.
arxiv  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

The boundness of Lusztig's $a$-function for Coxeter groups of finite rank [PDF]

open access: yesarXiv
We prove that the Lusztig's $a$-function is bounded for any Coxeter group of finite rank.
arxiv  

A New Technique for the Direct Measurement of the Electron Anti-Neutrino Mass [PDF]

open access: yesarXiv, 2006
Paper withdrawn because of unjustified approximation between equations 13 and 14.
arxiv  

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