Results 171 to 180 of about 1,068,414 (309)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The astronomical garden of Venus and Mars-NG915: the pivotal role of Astronomy in dating and deciphering Botticelli's masterpiece [PDF]

, 2018
M. Crosta
openalex   +1 more source

The Visual Monitoring Camera on Mars Express: calibrating a new science instrument made from an old webcam orbiting Mars

, 2022
Jorge Hernández-Bernal, Alejandro Cardesín‐Moinelo, R. Hueso, Eleni Ravanis, Abel Burgos Sierra, Simon N. Wood, Julia Marín-Yaseli de la Parra, Donald Merrit, Marc costa Sitja, Alfredo Escalante, Emmanuel Grotheer, P. Esquej, Miguel Almeida, Patrick Martin, Dima Titov, Colin Wilson, T. del Río‐Gaztelurrutia, A. Sánchez‐Lavega, Mar Sierra   +18 more
openalex   +1 more source

Validation of the Korean Moss Attention Rating Scale in Traumatic Brain Injury: Reliability and Validity. [PDF]

Korean J Neurotrauma
Jeong SH, Won JH, Oh BM, Kim JJ, Leigh JH, Shin G, Lee S, Lee HY.   +7 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Effects of Solar Wind Variations on the Martian Ionosphere and Ion Escape From Mars: Ion Species Dependence Based on MAVEN Observations

, 2023
K. Seki, Akira Kurosu, Takuya Hara, Brain David, Fowler Christopher, J. McFadden, J. S. Halekas, G. A. DiBraccio, R. J. Lillis, D. E. Larson, F. G. Eparvier, Shannon S. Currey   +11 more
openalex   +1 more source

Lightning-generated waves detected at Mars. [PDF]

Sci Adv
Němec F, Rosická K, Kolmašová I, Santolík O.   +3 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Controlled photomosaic of the Ismenius Lacus Southeast Quadrangle of Mars [PDF]

, 1982
U.S. Geological Survey
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source