Results 191 to 200 of about 473,493 (245)

Artificial Liver Support Effectively Removes Immunosuppressive Bile Acids From Circulation in Patients With Severe Liver Failure: A Proof of Concept Study. [PDF]

Crit Care Explor
Leonhardt J, Schmidt HH, Koball S, Dollinger M, Wilms C, Neugebauer S, Kunze J, Kiehntopf M, Hinz M, Backhus J, Henschel J, Klammt S, Sponholz C, Dominik A, Mitzner S, Stange J, Bauer M, Kortgen A.   +17 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

The structure of a complex, asymmetric coronal mass ejection revealed by 17 spacecraft across the inner heliosphere. [PDF]

Sci Adv
Luspay-Kuti A, Turner DL, Paouris E, Vourlidas A, Crew AB, McNutt RL, Westlake JH, Raptis S, Cochrane CJ, Jia X, Raymond CA, Korth H, Heyner D, Hanley K, Rahmati A, Gruesbeck JR, Halekas JS, Curry SM, Smith HT, Stevens ML, Roussos E, Mandt KE, Kivelson MG, Slavin JA, Waller D, Khurana KK, Nordheim TA, Paty CS, Rymer AM, Saur J, Krupp N.   +30 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Evaluation of fatty liver disease self-care applications: a systematic review and evaluation of apps using the mobile application rating scale (MARS). [PDF]

BMC Gastroenterol
Mohammadzadeh N, Daeechini AH, Paghe A, Laktarashi HV, Esmaeeli E.   +4 more
europepmc   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

What the Solar System Can Teach Us About Rocky Exoplanets. [PDF]

Space Sci Rev
Byrne PK, Guimond CM, Cawood PA, Way MJ, Breuer D, Spohn T, Duarte JC, Lourenço DL, Miozzi F, Arnould M, Coltice N, Olson SL.   +11 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Motor Aberrant Reinnervation Sequelae in Postparalytic Facial Synkinesis: A 35-year Evolution of Surgical Strategy. [PDF]

Plast Reconstr Surg Glob Open
Chuang DC, Tay JQ, Khoury A, Lu JC, Chang TN.   +4 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source