Results 211 to 220 of about 970,728 (295)

Evaluation of medical education mobile apps with MARS and MARuL in a TPACK informed model. [PDF]

Sci Rep
Rezaei M, Owrangi S, Jafari S.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Lane departure on combined curves: driver heterogeneity, centrifugal risk, and crash prevention. [PDF]

Sci Rep
Wang X, Zhang Y, Li Y, Yi X, Wang X, Hao G.   +5 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Identifying and Evaluating Patient-Centered Mobile and Web Apps for Patients With Chronic Spontaneous Urticaria: Systematic Search and Content Analysis.

JMIR Mhealth Uhealth
Glatzel C, Glatzel B, Dege T, Brückel L, Goebeler M, Schmieder A.   +5 more
europepmc   +1 more source

Systematic evaluation of commercially available pain-management mHealth apps for chronic pain in the United Kingdom. [PDF]

Br J Health Psychol
Harding RP, Gillett JL, Passaportis M, Miles E, Matcham F.   +4 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The Pros and Cons of Using Earth's High Background Radiation Areas as an Analog for Mars Colonization: A Critical Analysis. [PDF]

J Biomed Phys Eng
Mortazavi SA, Mortazavi SMJ, Vafapour H.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Anticipating incomplete patient-reported outcomes in schizophrenia: a machine learning approach to predict the occurrence of missing data. [PDF]

Health Qual Life Outcomes
Barbalat G, Plasse J, Chéreau-Boudet I, Gouache B, Legros-Lafarge E, Guillard-Bouhet N, Franck N.   +6 more
europepmc   +1 more source