Results 81 to 90 of about 140,234 (311)

International cooperation for Mars exploration and sample return [PDF]

The National Research Council's Space Studies Board has previously recommended that the next major phase of Mars exploration for the United States involve detailed in situ investigations of the surface of Mars and the return to earth for laboratory ...
Boynton, William V., Cameron, A. G. W., Carr, Michael H., Kitchell, Jennifer H., Levy, Eugene H., Mazur, Peter, Pace, Norman R., Prinn, Ronald G., Solomon, Sean C., Wasserburg, Gerald J.   +9 more
core   +1 more source

Human crew-related aspects for astrobiology research [PDF]

, 2011
Several space agencies and exploration stakeholders have a strong interest in obtaining information on technical and human aspects to prepare for future extra-terrestrial planetary exploration.
Foing, B.H., Pletser, V., Thiel, C.S.
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Novel Scene Segmentation Network for Mars Rover Images Incorporating an Enhanced ASPP and a Context Refinement Module

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
In extraterrestrial environments with limited prior information, the autonomous perception capability of rovers is crucial for exploration missions. Given the images captured by rover cameras, scene segmentation techniques can be utilized to accurately ...
Xiong Xu, Tao Cheng, Qipeng Chen, Yongjiu Feng, Huan Xie, Chao Wang, Yanmin Jin, Xiaohua Tong   +7 more
doaj   +1 more source

Mars integrated transportation system multistage Mars mission [PDF]

In accordance with the objective of the Mars Integrated Transport System (MITS) program, the Multistage Mars Mission (MSMM) design team developed a profile for a manned mission to Mars.

core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Mars Exploration: Research on Goal-Driven Hierarchical DQN Autonomous Scene Exploration Algorithm

Aerospace
In the non-deterministic, large-scale navigation environment under the Mars exploration mission, there is a large space for action and many environmental states.
Zhiguo Zhou, Ying Chen, Jiabao Yu, Bowen Zu, Qian Wang, Xuehua Zhou, Junwei Duan   +6 more
doaj   +1 more source

Planetary protection issues and human exploration of Mars [PDF]

A key feature of the Space Exploration Initiative involves human missions to Mars. The report describing the initiative cites the search for life on Mars, extant or extinct, as one of the five science themes for such an endeavor.
Devincenzi, D. L.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source