Results 111 to 120 of about 161,153 (334)
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Some Anticipated Science Results from "Local" Martian Sampling Site(s) [PDF]
Current planning for return of a surface sample of Mars planned. Scientific aims and more detailed objectives relating to (a) past/extant life, (b) surface processes and interactions, (c) planetary evolution, and (d) human exploration are summarized in ...
Nyquist, L. E., Rao, M. N., Shih, C. Y.
core +1 more source
NASA Strategic Roadmap Summary Report [PDF]
, 2005 In response to the Vision, NASA commissioned strategic and capability roadmap teams to develop the pathways for turning the Vision into a reality. The strategic roadmaps were derived from the Vision for Space Exploration and the Aldrich Commission Report
Bauer, Frank +9 more
core +1 more source
Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
wiley +1 more source
Complete Subsurface Elemental Composition Measurements With PING [PDF]
The Probing In situ with Neutrons and Gamma rays (PING) instrument will measure the complete bulk elemental composition of the subsurface of Mars as well as any other solid planetary body.
Parsons, A. M.
core +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Booster Obsolescence and Life Extension (BOLE) for Space Launch System (SLS) [PDF]
A human mission to the moon and Mars is the stated space exploration goal of the United States and the international community. To achieve these goals, NASA is developing the Space Launch System (SLS) and the Orion crew capsule as key elements in the ...
Fuller, Michael E. +4 more
core +1 more source
Effects and Solutions on the Human Body After Long-Duration Space Flights [PDF]
, 2019 During the Cold War, President John F. Kennedy made it a mission for the National Aeronautics and Space Administration (NASA) to accomplish a lunar landing and return to Earth.
Esquivel Patricio, Jose Jaime
core +1 more source
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source