Results 91 to 100 of about 80,898 (289)

The Goals and Approach of the Phoenix Mission for Evaluating the Habitabiity of the Northern Plains on Mars [PDF]

The first goal of the Mars Exploration program, as defined by the Mars Exploration Payload Analysis Group (MEPAG) is to determine if life ever arose on Mars [1]. The Phoenix landing site was chosen to sample near surface ground ice in the Northern Plains
Stoker, Carol R.
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Limits on Optical Counterparts to the Repeating Fast Radio Burst 20180916B from High-speed Imaging with Gemini-North/‘Alopeke

The Astrophysical Journal
We report on contemporaneous optical observations at ≈10 ms timescales from the fast radio burst (FRB) 20180916B of two repeat bursts (FRB 20201023 and FRB 20220908) taken with the ‘Alopeke camera on the Gemini-North telescope.
Charles D. Kilpatrick, Nicolas Tejos, Bridget C. Andersen, J. Xavier Prochaska, Consuelo Núñez, Emmanuel Fonseca, Zachary Hartman, Steve B. Howell, Tom Seccull, Shriharsh P. Tendulkar   +9 more
doaj   +1 more source

Towards Crew-Centered, Mission-Oriented Space Flight Training [PDF]

This poster describes a training approach that applies empirically derived principles of training to reimagining the overall design of NASA's space flight training program. The poster is focused specifically on the design of astronaut training for NASA's
Barshi, Immanuel, Dempsey, Donna L.
core   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

The challenges and benefits of lunar exploration [PDF]

Three decades into the Space Age, the United States is experiencing a fundamental shift in space policy with the adoption of a broad national goal to expand human presence and activity beyond Earth orbit and out into the Solar System.
Cohen, Aaron
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The New Horizons Extended Mission Target: Arrokoth Search and Discovery

The Planetary Science Journal
Following the Pluto flyby of the New Horizons spacecraft, the mission provided a unique opportunity to explore the Kuiper Belt in situ. The possibility existed to fly by a Kuiper Belt object (KBO), as well as to observe additional objects at distances ...
Marc W. Buie, John R. Spencer, Simon B. Porter, Susan D. Benecchi, Alex H. Parker, S. Alan Stern, Michael Belton, Richard P. Binzel, David Borncamp, Francesca DeMeo, S. Fabbro, Cesar Fuentes, Hisanori Furusawa, Tetsuharu Fuse, Pamela L. Gay, Stephen Gwyn, Matthew J. Holman, H. Karoji, J. J. Kavelaars, Daisuke Kinoshita, Satoshi Miyazaki, Matt Mountain, Keith S. Noll, David J. Osip, Jean-Marc Petit, Neill I. Reid, Scott S. Sheppard, Mark Showalter, Andrew J. Steffl, Ray E. Sterner, Akito Tajitsu, David J. Tholen, David E. Trilling, Harold A. Weaver, Anne J. Verbiscer, Lawrence H. Wasserman, Takuji Yamashita, Toshifumi Yanagisawa, Fumi Yoshida, Amanda M. Zangari   +39 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source