Results 71 to 80 of about 80,898 (289)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Review of boundary model studies in the Venusian and Martian induced magnetosphere

地球与行星物理论评
Although Venus and Mars do not have a global magnetic field but have atmospheres and ionospheres. During their coupling with the solar wind, the induced magnetospheres are created, as well as the boundaries of the bow shock and the magnetic pileup ...
Jiaqi Zhang, Ming Wang, Haoyang Sui, Zijian Guan, Jinyu Li, Kehan Du, Jianyong Lü   +6 more
doaj   +1 more source

Planetary mission summaries. Volume 1: Introduction and overview [PDF]

Tabular synopses of twelve missions are presented along with the Mariner Jupiter/Saturn 1977 mission for comparison. Mission definitions considered include: Mars Polar Orbiter; Mars Surface Sample Return; Mars Rover; Marine Jupiter/Uranus 1979 with ...

core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Marshall Space Flight Center Research and Technology Report 2019 [PDF]

Today, our calling to explore is greater than ever before, and here at Marshall Space Flight Centerwe make human deep space exploration possible. A key goal for Artemis is demonstrating and perfecting capabilities on the Moon for technologies needed for ...
Dankanich, John W., Morris, Heather C.
core   +1 more source

Scientific Goals and Objectives for the Human Exploration of Mars: 1. Biology and Atmosphere/Climate [PDF]

, 2008
To prepare for the exploration of Mars by humans, as outlined in the new national vision for Space Exploration (VSE), the Mars Exploration Program Analysis Group (MEPAG), chartered by NASA's Mars Exploration Program (MEP), formed a Human Exploration of ...
Anbar, A. D., Beaty, D. W., Bell, M. S., Clancy, R. T., Cockell, C. S., Connerney, J. E., Delory, G., Dickson, J. T., Doran, P. T., Elphic, R. C., Eppler, D. B., Fernandez-Remolar, D. C., Garvin, J. B., Gruener, J. E., Head, J. W., Heldmann, J., Helper, M., Hipkin, V., Lane, M. D., Levine, Joel S., Levy, J., Moersch, J., Ori, G. G., Peach, L., Poulet, F.   +24 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Nuclear thermal propulsion workshop overview [PDF]

NASA is planning an Exploration Technology Program as part of the Space Exploration Initiative to return U.S. astronauts to the moon, conduct intensive robotic exploration of the moon and Mars, and to conduct a piloted mission to Mars by 2019.
Clark, John S.
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Planetary Geology: Goals, Future Directions, and Recommendations [PDF]

Planetary exploration has provided a torrent of discoveries and a recognition that planets are not inert objects. This expanded view has led to the notion of comparative planetology, in which the differences and similarities among planetary objects are ...

core   +1 more source