Results 81 to 90 of about 80,898 (289)
Increased Science Instrumentation Funding Strengthens Mars Program [PDF]
, 2012 As the strategic knowledge gaps mature for the exploration of Mars, Mars sample return (MSR), and Phobos/Deimos missions, one approach that becomes more probable involves smaller science instrumentation and integrated science suites. Recent technological
Graff, T. G., Graham, Lee D.
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Nuclear thermal propulsion program overview [PDF]
Nuclear thermal propulsion program is described. The following subject areas are covered: lunar and Mars missions; national space policy; international cooperation in space exploration; propulsion technology; nuclear rocket program; and ...
Bennett, Gary L.
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Nuclear Electric Propulsion Technology Panel findings and recommendations [PDF]
Summarized are the findings and recommendations of a triagency (NASA/DOE/DOD) panel on Nuclear Electric Propulsion (NEP) Technology. NEP has been identified as a candidate nuclear propulsion technology for exploration of the Moon and Mars as part of the ...
Doherty, Michael P.
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Current Issues in Sport ScienceIntroduction and Purpose Space exploration is transitioning to a new era. NASA’s Artemis program is spearheading crewed missions to the Moon in the next decade, paving the way for eventual human exploration of Mars (Smith et al., 2020). However, space
Benjamin Reimeir +6 more
doaj +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Overview of Ka-band communications technology requirements for the space exploration initiative [PDF]
In the Space Exploration Initiative, Ka-band frequencies are likely to carry the bulk of the communications traffic both in the vicinity of and on the return links from the moon and Mars.
Miller, Edward F.
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source