Results 111 to 120 of about 80,898 (289)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

The Quest for Organic Carbon on Mars [PDF]

open access: yes
We are entering an era of Mars exploration in which organic carbon detection, characterization, and structural identification will be key to addressing some of the outstanding science objectives of the Mars Exploration Program.
Eigenbrode, Jennifer
core   +1 more source

Mission Programming for the Mars Moon eXplorer Mission

open access: yes, 2019
This thesis presents a way to maximise the photographic coverage of Phobos, one of the two Martian moons, as part of the space mission Mars Moon eXplorer. This coverage is performed by the French hyperspectral imager MacrOmega, and two criteria are selected: the area covered and the resolution of the pictures.
openaire   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

NASA's Chemical Transfer Propulsion Program for Pathfinder [PDF]

open access: yes
Pathfinder is a research and technology project, with specific deliverables, initiated by the National Aeronautics and Space Administration (NASA) which will strengthen the technology base of the United States civil space program in preparation for ...
Berkopec, Frank D.   +2 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

The Weak Stability Boundary, A Gateway for Human Exploration of Space [PDF]

open access: yes
NASA plans for future human exploration of the Solar System describe only missions to Mars. Before such missions can be initiated, much study remains to be done in technology development, mission operations and human performance.
Mendell, Wendell W.
core   +1 more source

Towards the Final Frontier: Using Strategic Communication Activities to Engage the Latent Public as a Key Stakeholder in a Corporate Mission [PDF]

open access: yes, 2018
Private corporations that do not normally interact with, nor regularly communicate with, the public often do not perceive the public as a relevant or active stakeholder.
D\u27Urso, Scott C.
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

EDL Pathfinder Missions [PDF]

open access: yes
NASA is developing a longterm strategy for achieving extended human missions to Mars in support of the policies outlined in the 2010 NASA Authorization Act and National Space Policy.
Drake, Bret G.
core   +1 more source

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