Results 71 to 80 of about 161,153 (334)

Planetary mission summaries. Volume 1: Introduction and overview [PDF]

Tabular synopses of twelve missions are presented along with the Mariner Jupiter/Saturn 1977 mission for comparison. Mission definitions considered include: Mars Polar Orbiter; Mars Surface Sample Return; Mars Rover; Marine Jupiter/Uranus 1979 with ...

core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

International cooperation for Mars exploration and sample return [PDF]

The National Research Council's Space Studies Board has previously recommended that the next major phase of Mars exploration for the United States involve detailed in situ investigations of the surface of Mars and the return to earth for laboratory ...
Boynton, William V., Cameron, A. G. W., Carr, Michael H., Kitchell, Jennifer H., Levy, Eugene H., Mazur, Peter, Pace, Norman R., Prinn, Ronald G., Solomon, Sean C., Wasserburg, Gerald J.   +9 more
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Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Nuclear thermal propulsion program overview [PDF]

Nuclear thermal propulsion program is described. The following subject areas are covered: lunar and Mars missions; national space policy; international cooperation in space exploration; propulsion technology; nuclear rocket program; and ...
Bennett, Gary L.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Review of boundary model studies in the Venusian and Martian induced magnetosphere

地球与行星物理论评
Although Venus and Mars do not have a global magnetic field but have atmospheres and ionospheres. During their coupling with the solar wind, the induced magnetospheres are created, as well as the boundaries of the bow shock and the magnetic pileup ...
Jiaqi Zhang, Ming Wang, Haoyang Sui, Zijian Guan, Jinyu Li, Kehan Du, Jianyong Lü   +6 more
doaj   +1 more source

The Goals and Approach of the Phoenix Mission for Evaluating the Habitabiity of the Northern Plains on Mars [PDF]

The first goal of the Mars Exploration program, as defined by the Mars Exploration Payload Analysis Group (MEPAG) is to determine if life ever arose on Mars [1]. The Phoenix landing site was chosen to sample near surface ground ice in the Northern Plains
Stoker, Carol R.
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Increased Science Instrumentation Funding Strengthens Mars Program [PDF]

, 2012
As the strategic knowledge gaps mature for the exploration of Mars, Mars sample return (MSR), and Phobos/Deimos missions, one approach that becomes more probable involves smaller science instrumentation and integrated science suites. Recent technological
Graff, T. G., Graham, Lee D.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source