Results 71 to 80 of about 3,590 (251)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Limits on Optical Counterparts to the Repeating Fast Radio Burst 20180916B from High-speed Imaging with Gemini-North/‘Alopeke

The Astrophysical Journal
We report on contemporaneous optical observations at ≈10 ms timescales from the fast radio burst (FRB) 20180916B of two repeat bursts (FRB 20201023 and FRB 20220908) taken with the ‘Alopeke camera on the Gemini-North telescope.
Charles D. Kilpatrick, Nicolas Tejos, Bridget C. Andersen, J. Xavier Prochaska, Consuelo Núñez, Emmanuel Fonseca, Zachary Hartman, Steve B. Howell, Tom Seccull, Shriharsh P. Tendulkar   +9 more
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

The New Horizons Extended Mission Target: Arrokoth Search and Discovery

The Planetary Science Journal
Following the Pluto flyby of the New Horizons spacecraft, the mission provided a unique opportunity to explore the Kuiper Belt in situ. The possibility existed to fly by a Kuiper Belt object (KBO), as well as to observe additional objects at distances ...
Marc W. Buie, John R. Spencer, Simon B. Porter, Susan D. Benecchi, Alex H. Parker, S. Alan Stern, Michael Belton, Richard P. Binzel, David Borncamp, Francesca DeMeo, S. Fabbro, Cesar Fuentes, Hisanori Furusawa, Tetsuharu Fuse, Pamela L. Gay, Stephen Gwyn, Matthew J. Holman, H. Karoji, J. J. Kavelaars, Daisuke Kinoshita, Satoshi Miyazaki, Matt Mountain, Keith S. Noll, David J. Osip, Jean-Marc Petit, Neill I. Reid, Scott S. Sheppard, Mark Showalter, Andrew J. Steffl, Ray E. Sterner, Akito Tajitsu, David J. Tholen, David E. Trilling, Harold A. Weaver, Anne J. Verbiscer, Lawrence H. Wasserman, Takuji Yamashita, Toshifumi Yanagisawa, Fumi Yoshida, Amanda M. Zangari   +39 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Constraining Near-simultaneous Radio Emission from Short Gamma-Ray Bursts Using CHIME/FRB

The Astrophysical Journal
We use the Canadian Hydrogen Intensity Mapping Experiment (CHIME) Fast Radio Burst (FRB) Project to search for FRBs that are temporally and spatially coincident with gamma-ray bursts (GRBs) occurring between 2018 July 7 and 2023 August 3.
Alice P. Curtin, Sloane Sirota, Victoria M. Kaspi, Shriharsh P. Tendulkar, Mohit Bhardwaj, Amanda M. Cook, Wen-Fai Fong, B. M. Gaensler, Robert A. Main, Kiyoshi W. Masui, Daniele Michilli, Ayush Pandhi, Aaron B. Pearlman, Paul Scholz, Kaitlyn Shin   +14 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Planet Masses, Radii, and Orbits from NASA’s K2 Mission

The Astrophysical Journal Supplement Series
We report the masses, sizes, and orbital properties of 86 planets orbiting 55 stars observed by NASA’s K2 Mission with follow-up Doppler measurements by the HIRES spectrometer at the W. M.
Andrew W. Howard, Evan Sinukoff, Sarah Blunt, Erik A. Petigura, Ian J. M. Crossfield, Howard Isaacson, Molly Kosiarek, Ryan A. Rubenzahl, John M. Brewer, Benjamin J. Fulton, Courtney D. Dressing, Lea A. Hirsch, Heather Knutson, John H. Livingston, Sean M. Mills, Arpita Roy, Lauren M. Weiss, Bjorn Benneke, David R. Ciardi, Jessie L. Christiansen, William D. Cochran, Justin R. Crepp, Erica Gonzales, Brad M. S. Hansen, Kevin Hardegree-Ullman, Steve B. Howell, Sébastien Lépine, Arturo O. Martinez, Leslie A. Rogers, Joshua E. Schlieder, Michael Werner, Alex S. Polanski, Isabel Angelo, Corey Beard, Aida Behmard, Luke G. Bouma, Casey L. Brinkman, Ashley Chontos, Fei Dai, Paul A. Dalba, Steven Giacalone, Samuel K. Grunblatt, Michelle L. Hill, Stephen R. Kane, Jack Lubin, Andrew W. Mayo, Teo Mocnik, Joseph M. Akana Murphy, Malena Rice, Lee J. Rosenthal, Dakotah Tyler, Judah Van Zandt, Samuel W. Yee   +52 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source