Results 81 to 90 of about 156,991 (333)

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

International cooperation for Mars exploration and sample return [PDF]

The National Research Council's Space Studies Board has previously recommended that the next major phase of Mars exploration for the United States involve detailed in situ investigations of the surface of Mars and the return to earth for laboratory ...
Boynton, William V., Cameron, A. G. W., Carr, Michael H., Kitchell, Jennifer H., Levy, Eugene H., Mazur, Peter, Pace, Norman R., Prinn, Ronald G., Solomon, Sean C., Wasserburg, Gerald J.   +9 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Increased Science Instrumentation Funding Strengthens Mars Program [PDF]

, 2012
As the strategic knowledge gaps mature for the exploration of Mars, Mars sample return (MSR), and Phobos/Deimos missions, one approach that becomes more probable involves smaller science instrumentation and integrated science suites. Recent technological
Graff, T. G., Graham, Lee D.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Goals and Approach of the Phoenix Mission for Evaluating the Habitabiity of the Northern Plains on Mars [PDF]

The first goal of the Mars Exploration program, as defined by the Mars Exploration Payload Analysis Group (MEPAG) is to determine if life ever arose on Mars [1]. The Phoenix landing site was chosen to sample near surface ground ice in the Northern Plains
Stoker, Carol R.
core   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Mars 94 Mission: Current plans and science [PDF]

The Soviet Space Program proposes large-scale investigations of Mars as one of the most important trends for the next 10 to 15 years. The objectives include global studies of the surface of Mars, its atmosphere, and the return of soil samples to Earth ...
Marov, Mikhail YA., Mukhin, Lev
core   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Neil Armstrong’s digital twin: An integrative approach for movement analysis in simulated space missions

Current Issues in Sport Science
Introduction and Purpose Space exploration is transitioning to a new era. NASA’s Artemis program is spearheading crewed missions to the Moon in the next decade, paving the way for eventual human exploration of Mars (Smith et al., 2020). However, space
Benjamin Reimeir, Anna Wargel, Franziska Riedl, Sara Maach, Robert Weidner, Gernot Grömer, Peter Federolf   +6 more
doaj   +1 more source