Results 51 to 60 of about 109,078 (345)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

A Hidden Life: Malick's Requiem

open access: yesChurch, Communication and Culture, 2020
The analysis of the narrative strategies in the writing of the script and in the formal finishing of the film A Hidden Life, the tenth feature film by the American director Terrence Malick, allows us to affirm that it is a work that is perfectly coherent
Alberto Fijo
doaj   +1 more source

Memory, tradition, and Christianization of the Peloponnese [PDF]

open access: yes, 2015
This work examines the use of memory and tradition in the Christianization of the Peloponnese based on the evidence of the location and topography of churches.
Sweetman, Rebecca Jane
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Simultaneous replacement of the aortic valve and hip joint in a patient with critical aortic stenosis and femoral neck fracture

open access: yesВестник хирургии имени И.И. Грекова
Concomitant cardiovascular diseases in elderly patients with a hip fracture significantly increase the risk of developing postoperative complications.
S. V. Petrov   +6 more
doaj   +1 more source

Actants in the ‘Object Donor List’:

open access: yesSanglap: Journal of Literary and Cultural Inquiry, 2021
An official process of the naming of ‘martyr’ by the National Freedom Fighter Council or inclusion of a person’s name in the list for martyr awards in Bangladesh depends on or at times is supplemented by enlistment in the ‘Object Donor List’.
Kusumita Datta
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

A „Divine Sanction” on the Revolt: The Cult of St. Demetrios of Thessalonike and the Uprising of Peter and Asen (1185–1186) [PDF]

open access: yes, 2012
The paper examines the role of the cult of St. Demetrius of Thessalonica as a tool of maintaining legitimacy of the anti-Byzantine revolt in Tărnovo, 1185–1186, led by brothers Theodore- Peter and Asen-Belgun, which is viewed in the modern scholarship ...
Dobyčina, Anastasia
core  

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

La guerre d’indépendance algérienne : une mémoire disputée dans le champ politique algérien

open access: yesCahiers d’histoire, 2016
Dans le contexte de la crise du régime politique algérien, l’enjeu de cette recherche est de faire une étude de l’opposition algérienne et de ses usages du passé.
Emmanuel Alcaraz
doaj   +1 more source

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