Results 71 to 80 of about 3,703 (254)
Between the announcement of her death sentence on November 19th, 1586, and her execution on February 8th, 1587, Mary Stuart wrote ten letters, most likely unbeknownst to her guards in the Fotheringhay castle. What may have motivated Mary Stuart to devote
Colette H. Winn
doaj +1 more source
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
L’honneur d’un fils de disparu
The experience of the son of an Algerian nationalist militant tortured and liquidated by the French army during the War of Independence, denied access, like so many others, to truth and justice, is put into perspective with the government's management of
Lætitia Bucaille
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La guerre d’indépendance algérienne : une mémoire disputée dans le champ politique algérien
Dans le contexte de la crise du régime politique algérien, l’enjeu de cette recherche est de faire une étude de l’opposition algérienne et de ses usages du passé.
Emmanuel Alcaraz
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Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Background: General health is affected by personality factors such as pessimism and self esteem. The present study was concerned with relationship between general health, pessimism, and self esteem in college students with father and martyr father in ...
Mokhtar Malekpour, Kourosh Banihashemian
doaj
ADP‐ribosylation: An emerging regulator of the epigenome
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Stefan Dečanski as a New Tobit [PDF]
Although it is considered part of the Deuterocanonical books of the Old Testament, the Book of Tobit has been highly popular among readers since the early Christian era.
Polovina Nataša M.
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