Results 71 to 80 of about 3,703 (254)

The Martyr Queen

open access: yesArts et Savoirs, 2016
Between the announcement of her death sentence on November 19th, 1586, and her execution on February 8th, 1587, Mary Stuart wrote ten letters, most likely unbeknownst to her guards in the Fotheringhay castle. What may have motivated Mary Stuart to devote
Colette H. Winn
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

L’honneur d’un fils de disparu

open access: yesCriminocorpus
The experience of the son of an Algerian nationalist militant tortured and liquidated by the French army during the War of Independence, denied access, like so many others, to truth and justice, is put into perspective with the government's management of
Lætitia Bucaille
doaj   +1 more source

La guerre d’indépendance algérienne : une mémoire disputée dans le champ politique algérien

open access: yesCahiers d’histoire, 2016
Dans le contexte de la crise du régime politique algérien, l’enjeu de cette recherche est de faire une étude de l’opposition algérienne et de ses usages du passé.
Emmanuel Alcaraz
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Relationship between General Health, Pessimism, and Self Esteem in College Students of Shiraz University of Medical Sciences with Father and Martyr Father

open access: yesمجله دانشکده پزشکی اصفهان, 2011
Background: General health is affected by personality factors such as pessimism and self esteem. The present study was concerned with relationship between general health, pessimism, and self esteem in college students with father and martyr father in ...
Mokhtar Malekpour, Kourosh Banihashemian
doaj  

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Stefan Dečanski as a New Tobit [PDF]

open access: yesZbornik Radova Filozofskog Fakulteta u Prištini
Although it is considered part of the Deuterocanonical books of the Old Testament, the Book of Tobit has been highly popular among readers since the early Christian era.
Polovina Nataša M.
doaj   +1 more source

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