Results 61 to 70 of about 19,035 (287)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2011 [Extract] John Henry Newman once described Richard Simpson, the nineteenth-century English Catholic intellectual, as "always flicking his whip at Bishops, cutting them in tender places, throwing stones at Sacred Congregations, and ...
Gallagher, Donat
core +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
(W)riting and (de)scribing martyrdom: The church’s construction of Manche Masemola
HTS Teologiese Studies/Theological Studies, 2020 The purpose of this article is to describe how the Manche Masemola narrative crafts and constructs her as a martyr; dying in defence of her faith in the face of fierce religious competition between her Sepedi culture and Anglican faith.
Sekgothe Mokgoatšana
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Les Dossiers du GRIHL, 2015 This study deals with the dramatisation of hagiographical legends in France, in the seventeenth century. We would like to shed light on the theatrical uses of the saint character, focusing on the way dramatists insert fiction into the legends.
Anne Teulade
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
, 2023 This article explicates a morality martyr homology with three characteristics: amoral actions against good characters, introspection, and a fatalistic final act.
Perks, Lisa
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source