Results 81 to 90 of about 365,360 (387)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Police culture and gender : revisiting the 'cult of masculinity'

, 2017
The ‘cult of masculinity’ has received much attention as a persistent and negative feature of police culture, with its impacts repeatedly being drawn upon to make sense of women’s lack of progression and representation within policing.
M. Silvestri
semanticscholar   +1 more source

Outsourcing elderly care to migrant workers: the impact of gender and class on the experience of male employers [PDF]

, 2015
This article, based on semi-structured interviews, addresses masculinity in the international division of reproductive labour through an analysis of the impact of gender and class on the outsourcing of elderly care services to migrant care workers.
Gallo, Ester, Scrinzi, Francesca
core   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Den orättvisaste orättvisan. Heroism och alternativ maskulinitet i Hans Erik Engqvists ungdomsroman Tredagarskriget

Barnboken: Tidskrift för Barnlitteraturforskning, 2014
”Wicked Wrongfulness. Heroism and Alternative Versions of Masculinity in Hans Erik Engqvist’s Young Adult Novel Three Days War”. This article examines the re-evaluation of modern masculinity in the YA novel Three Days War by the Swedish author Hans Erik ...
Olle Widhe
doaj   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

A Few Good Men: The Politics of Masculinity in Chinua Achebe’s Things Fall Apart and Arrow of God [PDF]

PostScriptum: An Interdisciplinary Journal of Literary Studies, 2018
This paper seeks to read into the nuances of masculinity in Chinua Achebe’s novels Things Fall Apart (1958) and Arrow of God (1964) and to understand how masculinity plays a crucial role in the power struggle between indigenous society and polity and the
Abrona Lee Pandi Aden
doaj   +1 more source

Prime beef cuts : culinary images for thinking 'men' [PDF]

, 2007
The paper contributes to scholarship theorising the sociality of the brand in terms of subject positions it makes possible through drawing upon the generative context of circulating discourses, in this case of masculinity, cuisine and celebrity ...
Angel M., Appadurai A., Bauman Z., Belk R. W., Benwell B., Bourdieu P., Bracken P., Bristor J., Brittan A., Brownlie D., Buchbinder D., Butler J., Butler J., Caru A., Cashmore E., Chalmers L. V., Charles N., Crewe B., De Certeau M., Douglas Brownlie, Dyer R., Freeman J., Goffman E., Green J., Hall S., Henley N. M., Hewer P., Holt D. B., Kozinets R., Lury C., Manovich L., Marx K., Miller D., Mort F., Mort F., Murcott A., Murcott A., Neuhaus J., Novero C., O'Sullivan J., Oakley A., Oliver J., Ostberg J., Paul Hewer, Pettinger L., Pilchner J., Rutherford J., Rutherford J., Schroeder J. E., Schroeder J. E., Schroeder J. E., Schroeder J. E., Scott L., Scott L., Seidler V., Tobias S. M., Trotta J., Warde A., Weber M., Wilk R., Wright C., Zafar R.   +61 more
core   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Re-Thinking Aspiration and Hegemonic Masculinity in Transnational Context

Masculinities and Social Change, 2014
This article offers a contribution to the on-going critical analysis of the concept hegemonic masculinity. However, not in a way that seeks the demise or supersession of the concept but rather to offer a theoretical development that brings into focus ...
Richard Howson
doaj   +1 more source