Results 41 to 50 of about 165,047 (263)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Psychoacoustic Models for Perceptual Audio Coding—A Tutorial Review

Applied Sciences, 2019
Psychoacoustic models of human auditory perception have found an important application in the realm of perceptual audio coding, where exploiting the limitations of perception and removal of irrelevance is key to achieving a significant reduction in ...
Jürgen Herre, Sascha Dick
doaj   +1 more source

Underwater Noise Monitoring with Real-Time and Low-Cost Systems, (The CORMA Experience)

Journal of Marine Science and Engineering, 2021
Marine life can be severely affected by anthropogenic underwater noise. This latter increased proportionally to the rise of human activities such as maritime traffic, marine civil engineering works, oil- and gas-related activities or offshore wind farms;
Paolo Diviacco, Antonio Nadali, Massimiliano Iurcev, Mihai Burca, Rodrigo Carbajales, Matteo Gangale, Alessandro Busato, Fabio Brunetti, Lorenzo Grio, Alberto Viola, Nikolas Potleca   +10 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Social Camouflaging and Its Association with Depression, Anxiety, and Personal Burnout Among Autistic and Non-Autistic Women in Poland

Journal for Perspectives of Economic Political and Social Integration
This study aimed to examine the differences between autistic and non-autistic women from Poland in terms of social camouflage, as well as levels of de-pression, generalized anxiety, and personal burnout.
Dominik Strzelecki
doaj   +1 more source

Eesti jõuluaja sanditajad [PDF]

Mäetagused, 2015
Article discusses Estonian mumming traditions at Christmastime: their spread, age and gender of the participants, costumes and masking, communication between the hosting family and the mummers, and the gifts given to the mummers.
Ülo Tedre
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Full Field Masking Causes Reversals in Perceived Event Order

Frontiers in Neuroscience, 2020
We generally experience a stable visual world in spite of regular disruptions caused by our own movements (saccades, blinks) or by the visual input itself (flashes, occlusions).
Samson Chota, Douglas McLelland, Louisa Lavergne, Eckart Zimmermann, Patrick Cavanagh, Rufin VanRullen   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source