Results 71 to 80 of about 570,203 (330)

Masking strategies to avoid the boar taint in meat products [PDF]

open access: yesJournal on Processing and Energy in Agriculture, 2022
Surgery to castrate male pigs can be substituted by the manufacture of "entire males". However, the meat of whole male animals may have an unpleasant sexual odor, i.e. - boar taint.
Županjac Miloš   +2 more
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

INVESTIGATING THE ROLES OF MECHANORECEPTIVE CHANNELS IN TACTILE APPARENT MOTION PERCEPTION: A VIBROTACTILE STUDY [PDF]

open access: yes, 2018
Tactile apparent motion (TAM) is a perceptual phenomenon in which consecutive presentation of multiple tactile stimuli creates an illusion of motion. Employing a novel tactile display device, the Latero, allowed us to investigate this.
Kim, Phill, Servos, Philip, Dr.
core   +1 more source

When cognition kicks in: Working memory and speech understanding in noise

open access: yesNoise and Health, 2010
Perceptual load and cognitive load can be separately manipulated and dissociated in their effects on speech understanding in noise. The Ease of Language Understanding model assumes a theoretical position where perceptual task characteristics interact ...
Jerker Ronnberg   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Feedback driven adaptive combinatorial testing [PDF]

open access: yes, 2011
The configuration spaces of modern software systems are too large to test exhaustively. Combinatorial interaction testing (CIT) approaches, such as covering arrays, systematically sample the configuration space and test only the selected configurations ...
Cohen, Myra B.   +4 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

The significance of memory in sensory cortex [PDF]

open access: yes, 2017
Early sensory cortex is typically investigated in response to sensory stimulation, masking the contribution of internal signals. Recently, van Kerkoerle and colleagues reported that attention and memory signals segregate from sensory signals within ...
Muckli, Lars, Petro, Lucy S.
core   +1 more source

Emotion Potentiates Response Activation and Inhibition in Masked Priming

open access: yesFrontiers in Integrative Neuroscience, 2012
Previous studies have shown that emotion can have two-fold effects on perception. At the object-level, emotional stimuli benefit from a stimulus-specific boost in visual attention at the relative expense of competing stimuli. At the visual feature-level,
Bruno eBocanegra, Rene eZeelenberg
doaj   +1 more source

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