Results 101 to 110 of about 356,034 (303)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Mass land valuation serves as a prerequisite for optimizing the taxation system in Ukraine
Zemleustrìj, Kadastr ì Monìtorìng ZemelʹThe article highlights the issue of multiple tax base systems. It analyzes that according to existing international mass appraisal standards, the market value should serve as the tax base.
R. Kuryltsiv, O. Myronov
doaj +1 more source
Mass appraisal models of the urban lands
Bulletin of Prydniprovs’ka State Academy of Civil Engineering and Architecture, 2015 Наведено аналіз основних типів моделей масової оцінки, виділених на основі єдності науково-економічних засад та математичної інтерпретації способу визначення вартості.
Drapikovsky, A. I., Ivanova, I. B.
openaire +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Machine learning models in mass appraisal for property tax purposes: a systematic mapping study
AestimumThe use of machine learning models in mass appraisal of properties for tax purposes has been extensively investigated, generating a growing volume of primary research. This study aims to provide an overview of the machine learning techniques used in this
Carlos Augusto Zilli +2 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
UCL (University College London) Libraries Masterplan: Masterplanning Report [PDF]
, 2008 BDP were appointed to undertake a Masterplan for the UCL Main Library and the UCL Science Library and to identify how these buildings could be re-ordered to significantly improve the quality of the library environment and to facilitate the delivery of
BDP (Building Design Partnership) +1 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source