Results 101 to 110 of about 5,188,005 (243)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A 70 year chronicle of the evolution of Echaurren Norte Glacier, Central Andes of Chile
Annals of GlaciologyThe Echaurren Norte Glacier mass balance time series is the longest in the Southern Hemisphere, thus it is—together with the Zongo Glacier in Bolivia—a reference glacier by the World Glacier Monitoring Service.
James McPhee +8 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Glacier mass balance Jamtalferner, Silvretta, Austria, 1988/1989
, 2013 The glacier mass balance of Jamtalferner has been measured annually since 1988/1989 with the direct/glaciological method. Winter mass balance has been determined for 1 May in all years.
Markl, Gerhard +3 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Glacier mass balance Jamtalferner, Silvretta, Austria, 2011/2012
, 2013 The glacier mass balance of Jamtalferner has been measured annually since 1988/1989 with the direct/glaciological method. Winter mass balance has been determined for 1 May in all years.
Markl, Gerhard +3 more
core +1 more source
AgronomyTo control heavy metal pollution effectively, prevention of heavy metal accumulations in agricultural soils should be the priority rather than remediation of heavy metal contamination.
Anni Wei +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
The Application of Mass Balance and Hydrodynamic/Pollutant Transport Models for Wetland Restoration
, 1996 This study deals with the use of mass balance and hydrodynamic/pollutant transport models for wetland restoration. The models were applied to Cootes Paradise marsh, located at the western end of Hamilton Harbour, Lake Ontario.
Prescott, Katherine
core