Results 101 to 110 of about 790,403 (306)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Recent trends in melting conditions on the Antarctic Peninsula and their implications for ice-sheet mass balance and sea level [PDF]
, 2006 Long-term records from meteorological stations on the Antarctic Peninsula show strong rising trends in the annual duration of melting conditions. In each case, the trend is statistically significant and represents a major increase in the potential for ...
Dowdeswell, J.A. +19 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Global resource extraction raises concerns about environmental pressures and the security of mineral supply. Strategies to address these concerns depend on robust information on natural resource endowments, and on suitable methods to monitor and model ...
Magnus Ericsson (10951155) +8 more
core +1 more source
Mass balance of Freya Glacier, Greenland, in 2007/2008
, 2014 Mass balance of Freya Glacier, Greenland, in 2007 ...
Daniel Binder (6979367) +7 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Mass balance of Freya Glacier, Greenland, in 2012/2013
, 2014 Mass balance of Freya Glacier, Greenland, in 2012 ...
Daniel Binder (6979367) +7 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Dynamics and mass balance of El Chichón crater lake, Mexico [PDF]
Geofísica Internacional, 2004 The mass balance of El Chichón crater lake is controlled by precipitations, evaporation and seepage through the lake bottom. The main non-meteoric source of water and Cl for the lake is a boiling spring (Soap Pool) discharging saline and neutral water ...
Nicholas R. Varley +2 more
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Glacier mass balance Jamtalferner, Silvretta, Austria, 2007/2008
, 2013 The glacier mass balance of Jamtalferner has been measured annually since 1988/1989 with the direct/glaciological method. Winter mass balance has been determined for 1 May in all years.
Markl, Gerhard +5 more
core +1 more source